Differin 0.1% Gel / Differin Cream 45g


Key Features:

  • Differin contains the retinoid Adapalene
  • Comes as either Differin gel or Differin cream
  • Prescription-based acne treatment product
  • Can be used children and adults over the age of 12 years


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Differin Gel & Differin Cream - A view from our expert

Sakib Mohammed

Sakib Mohammed

Advance Pharmacist Prescriber

“Differin 0.1% cream and gel are topical retinoids that are available on prescription. What makes them different from other acne products is that they don’t contain antibiotics. Studies show that Differin gel is a good choice for the topical treatment of acne vulgaris and has fewer side effects than other acne treatments.”

Differin cream and Differin Gel information

Key Facts:

Here’s the key information you need to know about Differin cream / Gel, a medication used to treat a wide variety of acne
Medication NameDifferin Cream
Differin Gel
Active IngredientAdapalene 0.1% w/w
Medication formCream
Used to treatMild to Moderate Acne
Available dosages0.1%
Other names by which this medication is knownDifferin 0.1% w/w Gel
Differin 0.1% w/w cream
Common side effects
Dry skin
Skin exfoliation (peeling)
Skin burning sensation
Who is this medication suitable forAdults
Children over 12 years
Do you need a prescription for it?Yes
How should it be used?To be applied to the affected areas once daily before bed
Patient Information LeafletDifferin Gel

Differin Cream

The benefits of Differin:

  • Differin treats acne by increasing cell turnover, helping natural skin exfoliation
  • Helps to keep pores unblocked and stops new acne from forming
  • Improves skin tone and texture
  • Clinically proven to reduce acne by 87% after 12 weeks of use
If you’re looking for an effective acne treatment that clears breakouts when they start, then Differin gel or Differin cream may be the answer. Differin products contain the active ingredient adapalene- a form of vitamin A that reduces blocked pores and increases the growth of new skin cells. Check our online clinic where you can buy Differin gel and have it delivered straight to your door.

What is Differin acne treatment?

Differin acne treatment is available in two formulations, a gel or cream. Differin gel is absorbed easier into the skin than Differin cream, but the cream can help moisturise the skin. Differin contains Adapalene, a type of retinoid derived from Vitamin A. Adapalene is an alternative to another popular retinoid, Tretinoin. It can prevent pores from getting blocked and reduce inflammation on the skin. Differin cream and gel are prescription-only products; however, they are available from Click2Pharmacy through the online clinic.

What is Differin adapalene gel used for?

Differin adapalene gel and cream are used to treat mild to moderate acne vulgaris. Differin can reduce the number and severity of pimples, whiteheads and blackheads associated with acne. You can use Differin cream or gel to treat acne on the face and all other parts of the body, such as the chest and back.

Who is Differin gel acne treatment suitable for?

Differin gel acne treatment can be used in adults and children over the age of 12 years. The same applies to Differin 0.1% cream.

How does Differin cream for acne work?

Differin cream for acne works in the same way as Differin gel. The retinoid Adapalene works in multiple ways; the first is to increase cell turnover, allowing natural exfoliation of the skin. Adapalene also reduces the number of keratin skin cells and unclogs the skin’s pores and sebaceous glands. By applying Differin 0.1% cream and gel, the excess oil (sebum) on the face is diminished. In addition, the anti-inflammatory properties of Adapalene reduce swelling and redness caused by acne, improving the skin’s tone and texture. Differin gel/cream can also prevent breakouts, thereby stopping the formation of new acne.

Alternatives to Differin

There are several products available from Click2Pharmacy to treat acne, however Aknemycin Plus also contains a retinoid with the added benefit of an antibiotic to kill bacteria causing acne. For further information:

How to buy Differin online

You can buy Differin online from Click2Pharmacy. We off Differin products as part of our prescription-based service. You will need to fill out a consultation form on our online clinic page, which is reviewed by one of our prescribing pharmacists. Once this is approved, you can proceed to buy Differin gel or Differin cream, delivered straight to your door.

How to use Differin gel for acne:

  • Wash the face and affected skin with a mild cleanser.
  • Gently pat the skin dry.
  • Apply a thin layer of Differin Gel or Cream over the entire face.
  • You can use a moisturiser once the product is fully absorbed into the skin.

How long does Differin gel or cream take to work?

Differin gel or cream starts to work immediately, and results may appear in as little as 2 weeks. However, it is recommended that Differin is used for up to 12 weeks to see significant results. With continued use, studies show that Differin gel can reduce acne by 87% after 12 weeks of use.

Differin adapalene gel 0.1%- acne treatment ingredients

Active ingredient: Adapalene 0.1% w/w Other ingredients: carbomer 940, propylene glycol (E1520), poloxamer 182, disodium edetate, methylparahydroxybenzoate (E218), phenoxyethanol, sodium hydroxide and purified water.

Differin warnings

Can Differin acne treatment be used in pregnancy and breastfeeding?

Differin acne treatment should NOT be used during pregnancy or if you are thinking to get pregnant. If you fall pregnant whilst using Differin, please discontinue use immediately and speak to your doctor. You CAN use Differin while breastfeeding. To avoid exposure to the baby, you should NOT apply the product to your chest. Differin is NOT suitable for people with eczema or broken skin. For external use only Keep out of the SIGHT and REACH of children

Side effects of Differin 0.1% gel and Differin 0.1% cream

Differin is generally well-tolerated, but there can be side effects. Common side effects include:
  • A burning sensation
  • dryness of the skin
  • redness of the skin
  • a rash
For most people, these common side effects are mild and usually peak around 2 to 4 weeks before resolving. If irritation becomes severe, please consult your doctor. Another side effect is the “Differin purge”, which can last up to 8 weeks. Within this phase, it may seem as though the acne has returned or has become worse. Although it may appear the treatment is not working, the purging of the skin is a normal part of the process.

Is Differin adapalene cream different to Differin adapalene gel?

Differin adapalene cream and Differin adapalene gel contain Adalepene 0.1%. Both work in the same way to treat acne. The only difference is in the formulation. People with dry skin may prefer Differin cream over the gel as the cream has moisturising properties. On the other hand, Differin gel may be more suited to oily skin.

How can I buy Differin gel online?

You can buy Differin gel online from Click2Pharmacy. Differin is a prescription-based product; you will need to fill out consultation form.

Can you use Differin gel for comedonal acne?

Differin gel is recommended for mild to moderate acne. As Differin contains the retinoid Adapalene, it can be used to treat comedonal acne.

Is Differin for acne the best treatment out there?

Differin gel or cream is a clinically proven treatment to clear acne and prevent breakouts. Although some people may experience fewer side effects with Differin than other topical retinoid treatments, it may not suit all skin types. The pharmacists at Click2Pharmcy can guide you on which acne treatment product may be best for you.

Can you use Differin cream for rosacea?

Rosacea was once known as “acne rosacea” but is now considered a different condition. Although Differin can be prescribed by dermatologists to treat rosacea, it cannot be prescribed online for this purpose.

Differin vs Tretinoin- which is best for acne?

Differin contains the retinoid Adapalene, and Tretinoin is also retinoid. Both can be used successfully to treat acne, but the main differences are that Tretinoin is more potent and may cause greater irritation. In addition, products that contain Tretinoin, such as Aknemycin plus, also contain an antibiotic, which Differin does not have.

Where can I buy Differin in the UK?

Differin is available online in the UK at Click2Pharmacy. We offer this product through a prescription-based service.

How long does Differin acne treatment (45g) last?

If used every day, a 45g tube of Differin gel should last up to 90 days.


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