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Aklief Cream 75g

  • Prescription retinoid cream for facial and truncal acne
  • Contains trifarotene to clear blackheads, whiteheads, and pimples
  • Buy online from Click2Pharmacy and get it delivered straight to your door.
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This treatment is inclusive of consultation & private prescription.
Fast & Free Delivery Options

Variety of delivery options including next day & free delivery.

100% UK-based Pharmacy

Pharmacy, clinic and prescribers based in Greater Manchester.

Free Online Consultations

Start your treatment with a quick and free online consultation.

Buy Aklief Cream

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Step 2: Choose a Treatment

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About Aklief Cream

Aklief Cream is a prescription-only topical retinoid used to treat acne on the face and trunk in adults and adolescents aged 12 years and older. It contains trifarotene 50 micrograms per gram, a fourth-generation retinoid that helps reduce blocked pores, blackheads, whiteheads, and inflammatory pimples.

Aklief works by regulating skin cell turnover and preventing pores from becoming clogged, reducing the number of acne lesions and improving skin texture. It is applied once daily to affected areas and is suitable for mild to moderate acne with comedones and inflammatory spots.

Medication Name Aklief Cream
Active Ingredient Trifarotene 50 micrograms per gram
Medication Form Topical cream
Used to Treat Acne vulgaris affecting the face and/or trunk
Available Size 75g pump
Who Can Use It Adults and adolescents aged 12 years and above
Prescription Required? Yes
How to Use Apply a thin layer once daily in the evening to clean, dry skin on affected areas of the face or trunk as directed by your doctor.
Patient Information Leaflet Aklief Cream – Patient Information Leaflet

What is Aklief Cream Used For?

Aklief Cream is used for the treatment of acne vulgaris by reducing inflammation and preventing blocked pores. It targets both comedonal and inflammatory acne, helping to improve overall skin clarity and texture on the face, chest, shoulders, and back.

Who is Aklief Cream Suitable For?

Aklief is suitable for adults and adolescents aged 12 years and over who have acne on the face or trunk.

Do not use Aklief if you:

  • Are pregnant, planning to become pregnant, or breastfeeding
  • Are allergic to trifarotene or any of the ingredients in the cream
  • Have cuts, abrasions, eczema, or sunburned skin

Consult your doctor if you are breastfeeding. Do not apply the cream to the chest area during breastfeeding.

How to Use Aklief Cream

  1. Prime the pump before first use by pressing up to 10 times until the cream appears.
  2. Apply once daily in the evening to clean, dry skin.
  3. Use one pump for the face (forehead, cheeks, nose, and chin) and up to three pumps for the chest, shoulders, and back.
  4. Do not exceed four pumps per day.
  5. Avoid contact with eyes, lips, mouth, and mucous membranes.
  6. Wash hands thoroughly after application.

You may use a moisturiser before or after applying Aklief to reduce dryness and irritation. Allow skin to dry between applications.

Possible Side Effects of Aklief Cream

Like all medicines, Aklief can cause side effects, although not everyone will experience them. Most side effects are mild and occur at the site of application.

Common (may affect up to 1 in 10 people):

  • Application site irritation or itching
  • Dry skin
  • Sunburn

Uncommon (may affect up to 1 in 100 people):

  • Skin pain or redness
  • Discolouration or loss of skin pigmentation
  • Rash or swelling
  • Allergic dermatitis

Rare (may affect up to 1 in 1000 people):

  • Hives (urticaria)
  • Skin burning or fissures
  • Darkening of the skin (hyperpigmentation)

If you experience severe redness, burning, or irritation, stop using Aklief and contact your doctor.

Warnings and Precautions

  • Do not use if pregnant or planning to become pregnant.
  • Avoid use on eczematous, broken, or sunburned skin.
  • Avoid excessive sunlight and sunbeds during treatment.
  • Use sunscreen with SPF 30+ and wear protective clothing when outdoors.
  • Do not combine with other retinoids or peeling agents unless prescribed.
  • Aklief contains ethanol and propylene glycol, which may cause mild skin irritation.

Storage Instructions

  • Store at room temperature.
  • Discard 6 months after first opening.
  • Keep out of the sight and reach of children.

Ingredients

Active ingredient: Trifarotene 50 micrograms per gram.
Other ingredients: Allantoin, cyclomethicone, ethanol, phenoxyethanol, propylene glycol (E1520), medium-chain triglycerides, purified water, and other emulsifiers.

Important Information

  • For external use only — do not swallow.
  • Apply once daily at night to affected skin only.
  • Avoid applying to sensitive areas such as eyes, lips, or mucous membranes.
  • Stop use and contact your doctor if severe irritation develops.
  • Use a gentle cleanser and moisturiser throughout treatment to reduce dryness.

Buy Aklief Cream Online from Click2Pharmacy

Aklief Cream is available through our acne treatment clinic following an online consultation with one of our qualified prescribers. Once approved, your medication will be dispensed and delivered discreetly to your door.

Aklief Cream 75g Reviews

Aklief Cream FAQs


Aklief Cream is used to treat acne vulgaris on the face and trunk by unblocking pores, reducing inflammation, and preventing new spots from forming.

Apply once daily in the evening to clean, dry skin on affected areas using a thin layer. Avoid contact with eyes and lips.

Yes, you can apply a moisturiser before or after Aklief to reduce dryness or irritation, allowing time between applications for the skin to dry.

No, Aklief must not be used during pregnancy or if planning to conceive. Stop use immediately if you become pregnant.

You can buy Aklief Cream 75g online from Click2Pharmacy after a quick consultation with one of our prescribers, with discreet home delivery.

Our Experienced UK-based Pharmacy Team

Clinical Consultant
MUDr, MRCEM, EBCEM, FRCEM
GMC no. 7176414

Pharmacist
MPharm
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Pharmacist
MPharm
GPhC no. 2046514

Page content authored by Amjad Khan, last reviewed by Mr Muhammad on 3rd November 2025.

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