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About Atovaquone and Proguanil
Medication Name | Atovaquone and Proguanil |
Type and Form of Medicine | Tablet |
What it Does | Prevents and treats malaria |
Active Ingredients | Atovaquone, Proguanil |
Strength | 250mg/100mg |
Size | 12 tablets, 24 tablets, 36 tablets, 48 tablets |
Patient Information Leaflet | Link |
What is Atovaquone and Proguanil?
Atovaquone and Proguanil is a combination medication used to prevent and treat malaria. Malaria is a serious disease caused by parasites that enter the body through the bite of an infected mosquito. This medication combines two active ingredients, atovaquone and proguanil, which work together to kill the parasites and prevent them from multiplying in the blood.
What are Atovaquone and Proguanil used for?
Atovaquone and Proguanil are primarily used to prevent and treat malaria. They are not used for treating acne. However, they may be prescribed for other conditions as determined by a doctor.
How do Atovaquone and Proguanil work?
Atovaquone and Proguanil work by interfering with the life cycle of the malaria parasite. Atovaquone inhibits the parasite’s mitochondrial electron transport, which is essential for energy production. Proguanil, on the other hand, inhibits dihydrofolate reductase, an enzyme necessary for the parasite’s DNA synthesis. Together, these actions prevent the parasite from multiplying and spreading in the blood, effectively treating and preventing malaria.
Who are Atovaquone and Proguanil suitable for?
Atovaquone and Proguanil are suitable for adults and children who need to prevent or treat malaria. However, they may not be suitable for everyone. People with severe kidney or liver problems, pregnant or breastfeeding women, and those allergic to any of the ingredients should not take this medication. Always consult a doctor or pharmacist before starting any new medication.
How to use/take Atovaquone and Proguanil
- Take the tablet with food or a milky drink.
- Swallow the tablet whole; do not crush or chew it.
- Take the medication at the same time each day.
Take Atovaquone and Proguanil once daily. Follow the prescribed dosage and schedule provided by your doctor.
To prevent malaria, start taking the medication 1-2 days before entering a malaria-endemic area, continue during your stay, and for 7 days after leaving the area.
Atovaquone and Proguanil Side Effects
Like all medications, Atovaquone and Proguanil can cause side effects. Below are some common, uncommon, and serious side effects.
Common Side Effects
- Headache
- Nausea
- Stomach pain
- Diarrhoea
Uncommon Side Effects
- Vomiting
- Rash
- Mouth ulcers
Serious Side Effects
- Severe allergic reactions
- Severe skin reactions
- Severe liver problems
For a full list of side effects, please refer to the patient information leaflet.
Atovaquone and Proguanil Ingredients
Active Ingredients: Atovaquone, Proguanil
Other Ingredients: Microcrystalline cellulose, low-substituted hydroxypropyl cellulose, povidone K30, sodium starch glycolate, magnesium stearate, hypromellose, titanium dioxide, macrogol 400, iron oxide yellow, iron oxide red.
Important Information
- Do not take if you are allergic to atovaquone, proguanil, or any other ingredients in the medication.
- Do not take if you have severe kidney or liver problems.
- Consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
- Inform your doctor of any other medications you are taking to avoid potential interactions.
- Store the medication in a cool, dry place away from direct sunlight.