Orlistat (the active ingredient in Xenical) promotes weight loss by decreasing the amount of dietary fat absorbed in your intestines. Lipase, an enzyme found in the digestive tract, helps break down dietary fat into smaller components, so it can be used or stored for energy. Orlistat inhibits the work of lipase. In clinical trials involving Xenical, average weight loss after one year was about 9.3 percent greater than that achieved with a placebo (sugar pill). All of the study patients were on a diet, and also increased their exercise during the trial.
So, how does it work? The lipase enzyme is still present in the digestive tract to break down dietary fat. However, Orlistat gets in the way and prevents the breakdown of fat into smaller components, thus creating fewer calories available for absorption.
When you swallow a pill of Orlistat (brand names Xenical, Orlipaste, and Zenical), the amount of dietary fat that can be broken down for absorption is reduced. This fat leaves your body through stools and unchanged, helping you lose weight.
Simple Enough? It sounds simple enough, but the way Orlistat actually works in your body is quite complicated. To understand how Orlistat works, you need to know more about lipase.
Even Coca-Cola comes with side-effects! Orlistat should not be taken if you have a medical condition that requires you to have a balanced diet with high amounts of fat, such as AIDS, cystic fibrosis or other diseases affecting the absorption of nutrients from food and medications (malabsorption syndrome). Headache, diarrhea and abdominal pain are possible side effects of orlistat.
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