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Clotrimazole Pessary contains clotrimazole 500mg, an antifungal medicine used to treat vaginal thrush. It works by killing the fungus causing a yeast infection and relieving symptoms like itching, soreness, and abnormal vaginal discharge.
| Medication Name | Clotrimazole Pessary 500mg |
| Active Ingredient | Clotrimazole 500mg |
| Other Ingredients | Macrogol 400, macrogol 1500, sodium hydrogen phosphate, sodium dihydrogen phosphate |
| Medication Form | Vaginal pessary with applicator |
| Used to Treat | Vaginal thrush (fungal infection) |
| Available Sizes | Single 500mg pessary with applicator |
| Who Can Use It | Adult women |
| Prescription Required? | No – Pharmacy(P) Medicine |
| Patient Information Leaflet | Clotrimazole – Patient Information Leaflet |
Clotrimazole Pessary 500mg is used to treat vaginal thrush (candidiasis), a fungal infection of the vagina and vulva. Thrush is one of the most common infections women experience, and it isn’t caused by poor hygiene.
It develops when a yeast called Candida grows more than usual. Candida lives in the vagina and other parts of the body without causing any symptoms, and the natural balance that keeps it under control can be upset by:
As the yeast multiplies, thrush can cause:
Symptoms vary from person to person. You may have several of these or only one of them.
A Clotrimazole Pessary contains clotrimazole, which is an antifungal medicine. Thrush is a fungal infection, so it needs an antifungal treatment to clear the cause rather than something that only soothes the symptoms.
You insert the pessary into the vagina using the applicator provided, where it dissolves and releases clotrimazole directly onto the area affected by the infection. Clotrimazole works on the yeast cells themselves by stopping them from multiplying. This allows the infection to clear, and symptoms should be gone within three days of treatment.
Because the treatment is delivered straight to the site of the infection, only a small amount of clotrimazole is absorbed into the bloodstream.
A Clotrimazole Pessary is suitable for adult women treating vaginal thrush. It isn’t suitable for anyone under 16, and at Click2Pharmacy, we can only supply it to women aged 18 and over.
However, Clotrimazole isn’t suitable for everyone, so you shouldn’t use it if you:
Speak to your doctor or pharmacist before treating yourself if you:
Some symptoms need checking rather than treating as internal thrush. See your doctor if you have:
A dose of clotrimazole can be used during pregnancy and while breastfeeding, but check with your doctor or midwife first. In pregnancy, the pessary should be inserted gently with your fingers rather than with the applicator.
Use the pessary at night, just before you go to sleep, so it has time to dissolve while you’re lying down. Wash your hands before you start and again once you’ve finished.
It helps to wear a panty liner while the pessary dissolves. You may notice a white, chalky residue afterwards, which is normal and doesn’t mean the treatment hasn’t worked. If you notice pieces of undissolved pessary, speak to your doctor or pharmacist, as the treatment may not have worked properly.
If your symptoms haven’t improved within seven days, speak to your doctor.
Like all medications, Clotrimazole thrush treatment can cause side effects, although not everyone experiences them. Most affect the area you’re treating and settle on their own.
After the pessary is inserted, you might notice:
If you’re allergic to the pessary, the reaction is likely to happen soon after you have used it.
Stop using it and tell your doctor straight away or contact your nearest A&E, if any redness, burning, pain, itching or swelling gets worse or if you notice:
For a full list of side effects, read the patient information leaflet. If you get any side effects, including any not listed here, tell your doctor or pharmacist. You can also report them through the Yellow Card Scheme.
Active ingredient: clotrimazole 500mg.
Other ingredients: lactose monohydrate, microcrystalline cellulose, lactic acid, maize starch, crospovidone, calcium lactate pentahydrate, magnesium stearate, colloidal anhydrous silica and hypromellose.
Each pack contains one white pessary sealed in a foil blister, along with an applicator for inserting it.
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You can have a second Clotrimazole if thrush comes back seven days or more after your first treatment. If you’re getting more than two episodes within six months, see your doctor instead of treating yourself again, as recurrent thrush sometimes needs a different approach.
A Clotrimazole Pessary and a Canesten pessary 500mg are the same treatment. Clotrimazole is the name of the medicine itself, and Canesten is a brand name it’s sold under, so both contain 500mg of clotrimazole and are used in exactly the same way. Unbranded packs work in the same way as the branded Canesten thrush ones.
The difference between the 500mg and the 200mg Clotrimazole Pessary is how long you use it for. Both contain the same antifungal medicine, but the 500mg pessary is a single dose that gives you the full course in one go, while the 200mg pessary is inserted once a night for three nights in a row.
Your partner only needs thrush treatment if they have symptoms of their own, like itching, redness or soreness. Thrush can be passed on during sex, so it’s best to avoid intercourse until your treatment is finished. A pessary treats the vagina only, so a partner with symptoms will need to see a pharmacist or doctor for their own treatment.
Oral fluconazole and clotrimazole pessaries can be used at the same time, but it is usually unnecessary because both treat the infection inside the vagina, and one course is normally enough to clear it.
A pharmacist or GP will usually advise you to take either a fluconazole capsule or a clotrimazole pessary, alongside an external clotrimazole cream for itching and soreness around the vulva. These can be bought as a combi pack.
If your symptoms are severe or thrush keeps coming back after treatment, speak to a pharmacist or doctor. They may suggest using more than one treatment or a longer course.
Page content authored by Amjad Khan, last reviewed by Mr Muhammad on 9th August 2026.



