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Maloff Protect contains atovaquone 250mg and proguanil hydrochloride 100mg, two antimalarial medicines that work together to prevent malaria. It is used by adults travelling to regions where malaria is present and helps protect against infection caused by the malaria parasite Plasmodium falciparum.
Maloff Protect works by stopping the malaria parasite from multiplying in the bloodstream after being transmitted by mosquito bites. For effective protection, it must be taken before, during, and after travel, alongside bite-avoidance measures such as insect repellent and mosquito nets.
Maloff Protect tablets are suitable for adults weighing 40 kg or more and are available in the 24 tablets pack size.
| Medication Name | Maloff Protect Tablets |
| Active Ingredients | Atovaquone 250mg & Proguanil Hydrochloride 100mg |
| Other Ingredients | Poloxamer 188, microcrystalline cellulose, povidone K30, sodium starch glycolate, magnesium stearate, hypromellose, titanium dioxide (E171), iron oxide red (E172), macrogols |
| Medication Form | Film-coated tablets |
| Used to Treat | Prevention of malaria |
| Available Sizes | Â 24 tablet pack |
| Who Can Use It | Adults aged 18 years and over (≥40 kg) |
| Prescription Required? | No |
| Patient Information Leaflet | Maloff Protect – Patient Information Leaflet |
Maloff Protect is used to prevent malaria in adults travelling to malaria-risk regions. It helps kill the malaria parasite after infection and reduces the risk of developing malaria when taken correctly.
Maloff Protect helps prevent malaria by targeting the Plasmodium falciparum parasite transmitted through mosquito bites. Its active ingredients, atovaquone and proguanil, work together to stop the parasite from multiplying and eliminate it before it can cause infection. Atovaquone disrupts the parasite’s energy production, while proguanil enhances its effect and prevents parasite growth inside red blood cells.
Maloff Protect starts working from the first dose but requires at least one day to provide full protection. For effective malaria prevention, it should be taken daily during travel and continued for 7 days after leaving the malaria-risk area.
Clinical studies show that atovaquone/proguanil is up to 95.8% effective at preventing malaria. For maximum protection, Maloff Protect should be used alongside mosquito precautions such as insect repellent, bed nets, and protective clothing, as no anti-malaria medication offers 100% protection.
Maloff Protect is suitable for adults aged 18 years and over who weigh at least 40 kg.
Do not take Maloff Protect if you:
Speak to a healthcare professional before use if you:
If you vomit within one hour of taking a dose, take another tablet immediately.
Do not take a double dose to make up for a missed dose.
The number of Maloff Protect tablets you need depends on how long you’ll be staying in a malaria-risk area. Each pack already includes the 9 extra tablets required to complete your course — 2 before travel and 7 after leaving the area.
Use the guide below to choose the correct quantity for your trip:
This ensures you have enough tablets to cover your entire trip and post-travel protection.
Very common side effects:
Common side effects:
Rare but serious reactions may include severe allergic reactions or serious skin reactions. Stop taking Maloff Protect and seek medical help immediately if these occur.
Page content authored by Amjad Khan, last reviewed by Mr Muhammad on 23rd January 2026.
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