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Panadol Extra Advance Tablets

  • Advanced pain relief formula with paracetamol and caffeine
  • Fast-acting Optizorb technology for quicker absorption
  • Relieves tough pain including migraines, backache, and toothache
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In stock

£4.89
24 hr tracked delivery once approved
Fast & Free Delivery Options

Variety of delivery options including next day & free delivery.

100% UK-based Pharmacy

Pharmacy, clinic and prescribers based in Greater Manchester.

Free Online Consultations

Start your treatment with a quick and free online consultation.

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About Panadol Extra Advance Tablets

Panadol Extra Advance Tablets provide a powerful dual-action formula for those seeking stronger relief than standard paracetamol. Each tablet combines 500mg of paracetamol with 65mg of caffeine, which acts as an amplifier to increase the pain-relieving effects of the paracetamol. Featuring patented Optizorb technology, these tablets are designed to break down and absorb faster, reaching the bloodstream quickly to tackle tough pain efficiently.

Panadol Extra Advance is suitable for adults and children over 12 years and is available in convenient pack sizes:

  • Panadol Extra Advance – 32 Tablets
Medication Name Panadol Extra Advance Tablets
Active Ingredients Paracetamol (500mg) and Caffeine (65mg)
Other Ingredients Starch pregelatinised, povidone k-25, calcium carbonate, crospovidone, alginic acid, magnesium stearate and microcrystalline cellulose. Tablet coating contains titanium dioxide (E 171), hypromellose, macrogol, polysorbate 80 and carnauba wax
Medication Form Film-coated tablets
Used to Treat Headache, migraine, backache, toothache, period pain, rheumatic pain, and fever
Available Sizes 32 tablet pack
Who Can Use It Adults and children aged 12 years and over
Prescription Required? No – Pharmacy (P) medicine
Patient Information Leaflet Panadol Extra Advance – Patient Information Leaflet

What Is Panadol Extra Advance Used For?

Panadol Extra Advance is formulated to provide extra-strength relief for persistent or tough pain. It is highly effective for migraines, tension headaches, backache, and muscular aches. Additionally, it helps reduce high temperatures (fever) and manages the aches and pains associated with colds and flu.

Who Is Panadol Extra Advance Suitable For?

This product is suitable for adults and children aged 12 years and over.

Do not use Panadol Extra Advance if you:

  • Are allergic to paracetamol, caffeine, or any other listed ingredients
  • Are taking any other medicines containing paracetamol
  • Are under 12 years old

Speak to a healthcare professional before use if you:

  • Have liver or kidney disease (including alcoholic liver disease)
  • Are underweight, malnourished, or regularly consume high amounts of alcohol
  • Have a severe infection (which may increase the risk of metabolic acidosis)
  • Are pregnant or breastfeeding (due to the caffeine content)

How to Use Panadol Extra Advance

  1. Check the foil packaging to ensure it is intact.
  2. Swallow the required dose with a drink of water.
  3. Wait at least 4 hours between doses.
  4. Do not exceed the maximum daily dose (8 tablets for adults, 4 tablets for children 12-15).

If symptoms persist for more than 3 days, or if your headache becomes persistent, consult your doctor.

Possible Side Effects of Panadol Extra Advance

Side effects are rare, but may include:

  • Allergic reactions such as skin rash or itching
  • Skin peeling or mouth ulcers
  • Unexplained bruising or bleeding
  • Breathing problems (more likely if you have had them with aspirin or ibuprofen)

Due to the caffeine content, some users may experience insomnia, restlessness, or jitteriness if they also consume high amounts of coffee or tea.

Warnings and Precautions

  • Contains Paracetamol: Do not take with any other paracetamol-containing products.
  • Overdose Warning: Seek immediate medical advice in the event of an overdose, even if you feel well, due to the risk of delayed liver damage.
  • Avoid excessive caffeine intake (tea, coffee, canned drinks) while taking these tablets.

Storage Instructions

  • Store below 25°C in a dry place.
  • Keep out of the sight and reach of children.
  • Do not use after the expiry date shown on the pack.

Panadol Extra Advance Tablets Reviews

Our Experienced UK-based Pharmacy Team

Clinical Consultant
MUDr, MRCEM, EBCEM, FRCEM
GMC no. 7176414

Pharmacist
MPharm
GPhC no. 2065469

Pharmacist
MPharm
GPhC no. 2046514

Page content authored by Amjad Khan, last reviewed by Dr Hussain Ahmad on 10th March 2026.

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