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Panadol Night Pain Tablets

  • Dual-action relief for nighttime pain and difficulty falling asleep
  • Treats backache, period pain, migraines, and muscle aches
  • Contains an antihistamine to aid rest and paracetamol to reduce pain
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£5.19
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Fast & Free Delivery Options

Variety of delivery options including next day & free delivery.

100% UK-based Pharmacy

Pharmacy, clinic and prescribers based in Greater Manchester.

Free Online Consultations

Start your treatment with a quick and free online consultation.

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About Panadol Night Pain Tablets

Panadol Night Pain Tablets are a specially formulated dual-action medication designed for the short-term relief of bedtime pain. Combining paracetamol and diphenhydramine hydrochloride, these tablets effectively target aches and pains that prevent you from falling asleep. Whether you are suffering from a persistent headache, backache, or muscle pain, Panadol Night helps reduce discomfort while the antihistamine component aids a restful night’s sleep.

Panadol Night Pain Tablets are suitable for adults and adolescents aged 16 years and over and are available in one pack size:

  • Panadol Night Pain – 20 Tablets
Medication Name Panadol Night Pain Tablets
Active Ingredients Paracetamol 500mg and Diphenhydramine Hydrochloride 25mg
Medication Form Film-coated tablets
Used to Treat Bedtime pain including headaches, migraine, backache, and rheumatic pain
Available Sizes 20-tablet pack
Who Can Use It Adults and children aged 16 years and over
Prescription Required? No – Pharmacy (P) medicine
Patient Information Leaflet Panadol Night – Patient Information Leaflet

What Is Panadol Night Used For?

Panadol Night is specifically used for the relief of nighttime pain such as headaches, migraines, backache, rheumatic and muscle pain, toothache, or period pain which is causing difficulty in falling asleep. The paracetamol acts as an analgesic to stop the pain, while the diphenhydramine induces drowsiness to help you rest.

Who Is Panadol Night Suitable For?

Panadol Night is suitable for adults and children aged 16 years and over.

Do not use Panadol Night if you:

  • Are allergic to paracetamol, diphenhydramine, or any other ingredients listed
  • Have already taken 4 doses of paracetamol during the day
  • Are taking any other antihistamines or sleep aids
  • Suffer from porphyria

Speak to a healthcare professional before use if you:

  • Have liver or kidney problems (including alcoholic liver disease)
  • Have glaucoma, epilepsy, or prostate problems
  • Have chronic obstructive pulmonary disease (COPD) or asthma
  • Are pregnant or breastfeeding
  • Are taking medications for anxiety, depression, or heart conditions

Ingredients

Other ingredients: Maize starch, starch pre-gelatinised, potassium sorbate (E 202), povidone, purified talc, stearic acid, hypromellose (E 464), titanium dioxide (E 171), lactose monohydrate, macrogol 400, triacetin, brilliant blue FCF (E 133), indigo carmine (E 132) and carnauba wax.

How to Use Panadol Night

  1. Take the tablets 20 minutes before you intend to go to sleep.
  2. Swallow two tablets with a glass of water.
  3. Do not exceed the recommended dose of two tablets per night.
  4. Only take this medication if you have not exceeded the daily paracetamol limit (4000mg) from other products.

Do not take for more than 7 nights in a row without consulting your doctor.

Possible Side Effects of Panadol Night

Common side effects:

  • Drowsiness, dizziness, or blurred vision
  • Dry mouth, nose, or throat
  • Gastrointestinal disturbances (e.g., upset stomach)
  • Coordination problems or restlessness

Serious side effects (Stop use immediately):

  • Allergic reactions (skin rash, swelling, or shortness of breath)
  • Unexplained bruising or bleeding
  • Sudden weight loss or yellowing of the skin/eyes (jaundice)

Warnings and Precautions

  • Avoid Alcohol: Do not consume alcohol while taking Panadol Night as it increases the sedative effect.
  • Driving Warning: This medication causes drowsiness; do not drive or operate machinery the next day if you feel groggy.
  • Liver Warning: Contains paracetamol. Do not take with any other paracetamol-containing products.

Storage Instructions

  • Store in the original package to protect from light.
  • Do not store above 25°C.
  • Keep out of the reach and sight of children.

 

Panadol Night Pain Tablets Reviews

Our Experienced UK-based Pharmacy Team

Clinical Consultant
MUDr, MRCEM, EBCEM, FRCEM
GMC no. 7176414

Pharmacist
MPharm
GPhC no. 2065469

Pharmacist
MPharm
GPhC no. 2046514

Page content authored by Amjad Khan, last reviewed by Dr Hussain Ahmad on 26th March 2026.

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