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Solpadeine Headache Soluble Tablets

  • Dual-action pain relief for headache and migraine
  • Soluble tablets for faster absorption
  • Contains paracetamol and caffeine
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Fast & Free Delivery Options

Variety of delivery options including next day & free delivery.

100% UK-based Pharmacy

Pharmacy, clinic and prescribers based in Greater Manchester.

Free Online Consultations

Start your treatment with a quick and free online consultation.

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Solpadeine Headache Soluble Tablets for Pain Relief

Medication Name Solpadeine Headache Soluble Tablets
Active Ingredients Paracetamol 500mg and Caffeine 65mg
Medication Form Effervescent (soluble) tablet
Used to Treat Headache, migraine, backache, rheumatic pain, toothache, sore throat, period pain, fever, aches and pains of colds and flu
Available Pack Sizes 16 tablets
Do you need a prescription? Pharmacy-only medicine – don’t need a prescription but under supervision of pharmacist
How should it be taken? Adults and children 16+: 2 tablets every 4-6 hours as required. Children 12-15: 1 tablet every 4-6 hours.
Patient Information Leaflet Available in product packaging

What are Solpadeine Headache Soluble Tablets used for?

Solpadeine Headache Soluble Tablets are pain relief tablets that can provide effective relief from a range of everyday pain and fever symptoms, including:

How do Solpadeine Headache Soluble Tablets work?

Each tablet contains a dual-action formula of paracetamol 500mg and caffeine 65mg.

Paracetamol is a well-established painkiller that also reduces fever. It works by blocking the signals in the brain that tell your body it is in pain and by lowering elevated body temperature when you are unwell.

Caffeine is added to enhance paracetamol’s effectiveness. Research has shown that caffeine can increase the speed and extent of paracetamol absorption, helping provide fast, effective pain relief.

How to Take Solpadeine Headache Soluble Tablets

Adults and children over 16 years: Take 2 tablets dissolved in water every 4-6 hours as required. Do not take more than 8 tablets in 24 hours.

Children aged 12-15: Take 1 tablet every 4-6 hours as needed. Do not take more than 4 tablets in 24 hours.

Do not take more frequently than every 4 hours, and do not exceed the recommended dose.

Do not give to children under 12 years.

Avoid too much caffeine in drinks such as coffee and tea while taking this medicine, as high caffeine intake can cause difficulty sleeping, shaking and an uncomfortable feeling in the chest.

Solpadeine Headache Soluble Tablets Side Effects

Like all medicines, Solpadeine Headache Soluble Tablets can cause side effects, though not everybody gets them. Generally, Solpadeine soluble tablets are well tolerated, and only a small number of people have had side effects.

Stop taking the tablets and tell your doctor immediately if you experience any of the following:

  • Allergic reactions, which could be severe, lke skin rash and itching, sometimes with swelling of the mouth or face, or shortness of breath
  • Skin rash, peeling, or mouth ulcers
  • Breathing problems – these are more likely if you have previously experienced them with other painkillers such as ibuprofen or aspirin
  • Unexplained bruising or bleeding
  • Nausea, sudden weight loss, loss of appetite, or yellowing of the eyes and skin

If you experience any side effects not listed here, speak to your doctor or pharmacist.

Solpadeine Headache Soluble Tablets Ingredients

Active ingredients: Paracetamol 500 mg and Caffeine 65 mg per tablet.

Other ingredients: Sodium hydrogen carbonate, sorbitol (E420), saccharin sodium, sodium laurilsulfate, citric acid anhydrous, sodium carbonate anhydrous, povidone and dimeticone.

Warnings and Precautions

  • Do not take if you are allergic to paracetamol, caffeine, or any of the other ingredients
  • Do not take alongside any other medicines containing paracetamol
  • Speak to your doctor first if you have liver or kidney disease, an intolerance to some sugars, or are on a controlled sodium diet – each tablet contains 427mg of sodium
  • If you take blood-thinning medicines such as warfarin and need a painkiller daily, speak to your doctor before using this product. Occasional doses alongside anticoagulants are generally acceptable
  • Do not use during pregnancy or while breastfeeding due to the caffeine content
  • If you take too many tablets, seek immediate medical advice, even if you feel well; paracetamol overdose can cause serious liver damage that may not be apparent straight away
  • If your symptoms continue or your headache becomes persistent, see your doctor

Solpadeine Headache Soluble Tablets Reviews

Solpadeine Headache Soluble Tablets FAQs


Solpadeine Headache Soluble Tablets are available over the counter without a prescription. You can buy Solpadeine headache soluble tablets online from Click2Pharmacy and have them delivered quickly and discreetly to your door.

You don’t need to take Solpadeine headache tablets with food. Simply dissolve the required number of tablets in a tumbler of water and drink the solution. If you find paracetamol-based medicines upset your stomach, taking them with or after food is a reasonable approach.

You can take soluble paracetamol every 4 to 6 hours as needed. Adults and children aged 16 and over should not take more than 8 tablets in 24 hours. Children aged 12 to 15 should not take more than 4 tablets in 24 hours. Never take a dose more frequently than every 4 hours.

Solpadeine Headache Soluble Tablets do not need to be refrigerated. Store them at room temperature below 30°C, and keep them out of reach and out of sight of children.

The effervescent format means the tablets dissolve quickly in water, which can help the active ingredients be absorbed faster than a standard tablet. Most people can expect to feel relief within 30 to 60 minutes of taking the recommended dose. If your headache persists or becomes more frequent, speak to your doctor.

Our Experienced UK-based Pharmacy Team

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GMC no. 7176414

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Page content authored by Amjad Khan, last reviewed by Mr Muhammad on 9th March 2026.

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