If you’re looking into weight loss treatment in the UK, two options you might come across are Nevolat and Mounjaro. Both are prescription-only injectable medicines, both can support significant weight loss, and both are injected under the skin – but that’s where the similarities end.
| Nevolat | Mounjaro | |
| Active ingredient | Liraglutide | Tirzepatide |
| Drug class | GLP-1 receptor agonist | Dual GIP and GLP-1 receptor agonist |
| How it’s given | Injection under the skin | Injection under the skin |
| How often | Once a day | Once a week |
| Starting dose | 0.6mg | 2.5mg |
| Maximum dose | 3.0mg | 15mg |
| Licensed in the UK for | Weight management | Weight management and type 2 diabetes |
Nevolat is a prescription weight loss injection that contains the active ingredient liraglutide. It belongs to a group of medicines called GLP-1 receptor agonists, which work by mimicking a natural hormone in your body called glucagon-like peptide-1 (GLP-1).
Nevolat is a generic version of liraglutide for weight management, with Saxenda as the original brand name.
GLP-1 regulates your appetite – when you eat, your body releases it to signal fullness to your brain. Nevolat injections boost this signal, so you feel satisfied with less food and stay fuller for longer between meals. They also slow down how quickly food leaves your stomach, which helps reduce hunger and cravings.
In the UK, Nevolat is licensed for weight management in adults with a BMI of 30 or above, or a BMI of 27 or above with weight-related health conditions such as type 2 diabetes, high blood pressure, or sleep apnoea. It’s used alongside a reduced-calorie diet and more physical activity.
Mounjaro is a prescription weight loss and diabetes injection that contains the active ingredient tirzepatide. First introduced as a diabetes drug, it’s now also widely used as a weight loss drug in the UK and was the first medicine of its kind to act on two natural gut hormones at once.
Where Nevolat targets one hormone pathway, Mounjaro targets two: GLP-1 and GIP (glucose-dependent insulinotropic polypeptide). Both hormones help regulate appetite, blood sugar, and how your body processes food after a meal. By mimicking both at once, Mounjaro reduces hunger, slows stomach emptying and helps you feel fuller for longer after eating.
In the UK, Mounjaro is licensed for two purposes:
Like Nevolat, it’s used alongside a reduced-calorie diet and more physical activity.
Because Nevolat and Mounjaro work on similar hormone pathways, they share many of the same potential side effects. Most are related to digestion, and most people find they ease off as the body gets used to the medicine.
The most common side effects of both weight loss medications include:
These effects are usually worse when you first start treatment or move up to a higher dose, and tend to settle within a few days or weeks.
Both medicines can cause more serious side effects, but this is less common. These include gallbladder problems such as gallstones, inflammation of the pancreas (pancreatitis), and low blood sugar (more likely if you’re also taking other diabetes medication).
Speak to a clinician straight away if you have severe stomach pain that won’t go away, signs of an allergic reaction, or symptoms of low blood sugar like dizziness, shaking, or confusion.
Both medicines belong to the same family of medicated weight loss injections and are useful weight management tools, but the differences between them affect how they’re used, how well they work, and which one best suits your weight loss goals.
Nevolat contains liraglutide. Mounjaro contains tirzepatide. Both are types of medicine that mimic the actions of gut hormones involved in appetite and blood sugar control. The difference comes down to how many hormones they act on. Liraglutide works on one (GLP-1). Tirzepatide works on two (GLP-1 and GIP).
Both medicines slow down how quickly your stomach empties and reduce hunger signals to your brain. The result is that you feel fuller for longer and eat less.
Mounjaro also acts on GIP, a second hormone that helps regulate insulin and can also affect appetite and how the body uses fat. This dual action is what tends to make tirzepatide produce greater weight loss at higher doses.
Nevolat is a daily injection. You’ll inject at the same time each day into your stomach, thigh, or upper arm. The starting dose is 0.6mg, and you’ll gradually move up to the full 3mg dose over five weeks.
Mounjaro is a weekly injection. You’ll inject once a week into your upper arm, thigh or stomach, starting at 2.5mg and increasing every four weeks if your clinician recommends, up to a maximum of 15mg.
For people who don’t like the idea of injecting every day, a weekly dosing schedule can feel more manageable. Others prefer a smaller daily dose to keep them in the routine.
Both medicines can produce meaningful weight loss results when used alongside diet and exercise, but results differ.
In clinical trials:
Mounjaro may produce stronger results overall, but individual outcomes depend on starting weight, dose, lifestyle changes, and how your body responds to the medicine.
For many people, either option can be an effective weight loss treatment when used as part of long-term weight management.
At Click2Pharmacy, you can explore weight loss solutions like Mounjaro and Nevolat through a short online consultation. Your information will be reviewed by a UK-registered prescriber and pharmacist who will assess whether treatment is right for your weight loss goals.
If treatment is suitable, your medicine will be dispatched discreetly to your door, with ongoing support throughout your treatment to help you reach a healthy weight.
Start your online consultation today and let us support your weight loss journey.
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