Epiduo gel (Adapalene and Benzoyl Peroxide) 45g


Key Features:

  • Dual-action mechanism of Epiduo gel adapalene and benzoyl peroxide
  • Kills acne causing bacteria
  • Visible results in 4 weeks
  • Available in regular strength and stronger strength

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Epiduo Gel - A view from our expert

Sakib Mohammed

Sakib Mohammed

Advance Pharmacist Prescriber

“Epiduo gel is a medicine clinically proven to treat mild to moderate acne if you have mostly whiteheads and blackheads with a few papules and pustules. What makes Epiduo gel/cream work so well is that it has two key ingredients that work together to eradicate acne. You can use Epiduo when other single treatments have failed. Another advantage of Epiduo topical gel is that it doesn’t contain antibiotics, which is great for people who cannot tolerate them.

You do need a prescription for this medicine, but the good news is you can buy Epiduo gel from the online clinic at Click2Pharmcy. We have a team of prescribing pharmacists that can check if the medication is suitable for you. All you have to do is to fill out a consultation form. If you have any questions or concerns, we are here to help.”

Epiduo Gel information

Epiduo Gel Key Facts:

Here’s the key information you need to know about Epiduo Gel, a medication used to treat moderate to severe acne. It is also available as a stronger strength Epiduo 0.3% / 2.5%

Medication NameEpiduo Gel
Active Ingredientadapalene and benzoyl peroxide
Medication formGel
Used to treatMild to Moderate
Available dosagesEpiduo 0.1%/0.25% gel
Epiduo 0.3%/0.25% gel
Other names by which this medication is knownEpiduo Acne Gel
Epiduo Gel
Common side effects
Itching, peeling, or burning skin
Redness of the skin
Who is this medication suitable forAdults
Children over 9 years
Do you need a prescription for it?Yes
How should it be used?Apply a thin film of gel to whole of affected area daily.
Patient Information LeafletEpiduo Patient Information Leaflet

How can I buy Epiduo gel online? Usually, any prescription medication would require an appointment with the doctor, but at Click2Pharmacy, we have prescribing pharmacists. This means you can buy Epiduo gel directly from us. All you need to do is fill out a consultation form, which our team will review. Once approved, your medication will be delivered to your door

The Benefits of Epiduo Gel:

  • Dual-action mechanism of adapalene and benzoyl peroxide
  • Kills acne causing bacteria
  • Visible results in 4 weeks
  • Get Epiduo online and get it delivered straight to your door
  • Stronger version Epiduo gel 0.3% / 2.5% available

Is your acne out of control? Have you tried creams and ointments that don’t work? Epiduo Gel may be the treatment for mild to moderate acne. Epiduo acne treatment is prescription only and available to buy at Click2Pharmacy.

What is Epiduo gel?

Epiduo gel is a topical medicine designed to treat mild to moderate acne. Epiduo acne treatment is applied directly onto the skin. It is available in two different strengths of 0.1%/0.25% and 0.3/0.25%. You can buy Epiduo on prescription through our online clinic.

How does Epiduo acne gel work?

Epiduo acne gel has the active ingredients adapalene and benzoyl peroxide. Adapalene works in the same way as retinoids by reducing inflammation and unblocking pores on the skin. Benzoyl peroxide has antimicrobial properties; it kills the bacteria that cause acne and breaks down whiteheads and blackheads. Epiduo adapalene and benzoyl peroxide gel does not contain antibiotics.

Who is Epiduo acne cream suitable for?

Epiduo acne cream or gel can be used by adults and children over the age of 9 years.

For further information:

How to use Epiduo gel acne medication

Epiduo gel acne medication should be used once a day in the evenings.  Apply a thin layer of Epiduo gel to clean, dry skin. You should apply the gel to the whole affected area, not just spots.

If you find your skin feels irritated, try using Epiduo spot treatment a few times a week, and build up to daily use. Use continuously for 3 months.

Epiduo adapalene benzoyl peroxide gel Ingredients

Active ingredients: adapalene and benzoyl peroxide

Inactive ingredients: docusate sodium, disodium edetate, glycerin, poloxamer, propylene glycerol (E1520), simulgel 600 PHA (copolymer of acrylamide and sodium acryloyldimethyltaurate, isohexadecane, polysorbate 80, sorbitan oleate) & purified water.

Epiduo Side effects

Common side effects of Epiduo benzoyl peroxide/adapalene 

The side effects below affect between 1% and 10% of people:

  • Dry skin
  • Skin peeling
  • Contact dermatitis
  • Irritation and burning of the skin
  • Worsening of acne

You can minimise these side effects by using a non-comedogenic moisturiser and reducing the frequency of applying Epiduo gel, until the skin becomes used to the medicine. Within the first 4 weeks of use, you may experience skin purging where the skin looks worse before it starts to look better. Skin purging is part of the process of the renewal of skin cells.

If you experience any severe side effects listed below, you should stop using Epiduo prescription gel immediately and seek medical help.

  • Severe rash
  • Dizziness
  • Trouble breathing

Please check the patient information leaflet (PIL) for a full list of side effects.

For external use only

Keep out of the SIGHT and REACH of children

Epiduo Warnings

Epiduo topical treatment should NOT be used on skin that is broken or has eczema. It is recommended to avoid exposure to UV light whilst using this product.

Please note benzoyl peroxide has bleaching properties, so avoid contact with coloured fabrics.

Can Epiduo gel be used in pregnancy and breastfeeding?

Epiduo medication is NOT safe for use in pregnancy. As the effects of Epiduo on breastmilk are unknown, it is NOT recommended for breastfeeding. If you find you are pregnant whilst using Epiduo gel, you should stop use immediately.

Can I buy Epiduo online without a prescription?

You cannot buy Epiduo online without a prescription. You should buy Epiduo from a registered UK pharmacy

How can I get a prescription to buy Epiduo gel online?

Click2Pharmacy is a UK registered Pharmacy. You can get an Epiduo prescription online through our clinic. You will need to answer some questions first to check if you are suitable for Epiduo acne gel.

Is Epiduo benzoyl peroxide gel better than Duac gel?

Both Epiduo and Duac gel contain benzoyl peroxide, but Duac contains the antibiotic clindamycin. Both products effectively treat acne, but for people who cannot tolerate antibiotics, Epiduo gel may be a better option.

Is Epiduo gel for pimples effective?

You can use Epiduo for pimples. The higher strength Epiduo 0.3%/ 0.25% gel works effectively on pustules and papules (also called “pimples”).

Is Epiduo gel 0.3% better than Epiduo gel 0.1%

Epiduo gel 0.1% / 2.5% is recommended if you mostly have whiteheads and blackheads. However if comedones and numerous papules and pustules are present, it may be better to use the higher strength Epiduo gel 0.3% / 2.5%.

Can I use Epiduo anti-acne gel with other acne treatments?

You can use Epiduo acne gel alongside antibiotic treatments such as Erythromycin, Tetralysal (lymecycline) and Oxytetracycline. However, you cannot use Epiduo with other acne creams as they may irritate your skin.

Can Epiduo adapalene and benzoyl peroxide gel irritate the skin?

Skin irritation is a common side effect of Epiduo adapalene and benzoyl peroxide gel. This is due to the skin getting used to adapalene. Some people also experience skin purging, where the acne appears worse before it gets better. It is advisable to use Epiduo gel less frequently before building up to daily use to overcome skin irritation.


We are regulated by the General Pharmaceutical Council

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Our pharmacy and clinic is based in Greater Manchester. Our prescibers are in house

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