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Differin Gel Adapalene 0.1% / Differin Cream Adapalene 0.1%


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Key Features

  • Differin cream and gel contain the retinoid adapalene
  • Comes as either Differin gel adapalene or Differin cream adapalene
  • Buy online from a UK-licensed pharmacy following a free consultation
  • Can be used by children and adults over the age of 12 years


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Buy Differin Gel Adapalene & Cream Online

Differin acne treatment is available in two formulations: a Differin Gel Adapalene or Cream Adapalene. The active ingredient in Differin Cream and Gel is Adapalene, a type of retinoid derived from Vitamin A. Adapalene is an alternative to another popular retinoid, Tretinoin. It can prevent pores from getting blocked and reduce inflammation in the skin. Differin Gel Adapalene and Cream Adapalene are prescription-only products. You can buy Differin online from Click2Pharmacy through our online acne treatment clinic.

Key Facts:

Here’s the key information you need to know about Differin Adapalene Gel, a medication used to treat a wide variety of acne

Medication NameDifferin Cream
Differin Gel
Active IngredientAdapalene 0.1% w/w
Medication formCream
Used to treatMild to Moderate Acne
Available dosages0.1%
Other names by which this medication is knownDifferin 0.1% w/w Gel
Differin 0.1% w/w cream
Common side effects
Dry skin
Skin exfoliation (peeling)
Skin burning sensation
Who is this medication suitable forAdults
Children over 12 years
Do you need a prescription for it?Yes
How should it be used?To be applied to the affected areas once daily before bed
Patient Information LeafletDifferin Gel

Differin Cream

How to Buy Differin Online

You can buy Differin Adapalene Gel or Cream online from Click2Pharmacy. We offer Differin products as part of our prescription-based service. You will need to fill out a consultation form on our online acne clinic, which is reviewed by one of our prescribing pharmacists. Once this is approved, you can proceed to buy Differin Gel or Differin Cream, delivered straight to your door.

What is Differin Gel Adapalene used for?

Over a third (34%) of UK adults have suffered from acne at some point in their life. Differin adapalene gel and cream are used to treat mild to moderate acne vulgaris. Differin can reduce the number and severity of pimples, whiteheads and blackheads associated with acne. You can use Differin cream or gel to treat acne on the face and all other parts of the body, such as the chest, back or shoulders.

Who is Differin Gel Adapalene Acne Treatment suitable for?

Differin gel acne treatments can be used in adults and children over the age of 12 years. The same applies to Differin cream 0.1%.

How does Differin cream for acne work?

Differin cream for acne works in the same way as Differin gel. The retinoid Adapalene works in multiple ways; the first is to increase cell turnover, allowing natural exfoliation of the skin. Adapalene also reduces the number of keratin skin cells and unclogs the skin’s pores and sebaceous glands. By applying Differin gel 0.1% and cream, the excess oil (sebum) on the face is diminished. In addition, the anti-inflammatory properties of Adapalene reduce swelling and redness caused by acne, improving the skin’s tone and texture. Differin gel/cream can also prevent breakouts, thereby stopping the formation of new acne.

The Benefits of Differin:

  • Differin treats acne by increasing cell turnover, helping natural skin exfoliation
  • Helps to keep pores unblocked and stops new acne from forming
  • Improves skin tone and texture
  • Clinically proven to reduce acne by 87% after 12 weeks of use

How to Use Differin Adapalene Gel for Acne

  • Wash the face and affected skin with a mild cleanser.
  • Gently pat the skin dry.
  • Apply a thin layer of Differin Gel or Cream over the entire face.
  • You can use a moisturiser once the product is fully absorbed into the skin.

How long does Differin gel or cream take to work?

Differin gel or cream starts to work immediately, and results may appear in as little as 2 weeks. However, it is recommended that Differin is used for up to 12 weeks to see significant results. With continued use, studies show that Differin gel can reduce acne by 87% after 12 weeks of use.

Side Effects of Differin Gel Adapalene 

Like all medications, taking Differin Gel or cream comes with side effects:

Common Side effects:

  • Dry or irritated skin
  • Burning sensation on the skin 
  • Redness of the skin

Uncommon Side Effects:

  • Skin discomfort
  • Sunburn 
  • Itching or peeling of the skin
  • Acne 

If you experience swelling of the face, lips or throat which makes it difficult to swallow or breathe, rash, itching, hives and dizziness, this could be a sign of angioedema or a severe allergic reaction, so call 999 immediately. 

Not everyone will experience side effects when taking Differin Gel Adapelene or Cream Adapelene. If you get any of these side effects, talk to your doctor or pharmacist. See the patient information leaflet for a full list of side effects.

Important Information

  • Differin cream and gel are NOT suitable for people with eczema or broken skin.
  • For external use only.
  • Keep out of the SIGHT and REACH of children.

Differin Adapalene Gel & Differin Adapalene Cream - A view from our expert

Picture of Sakib Mohammed

Sakib Mohammed

Advance Pharmacist Prescriber

“Differin 0.1% cream and gel are topical retinoids that are available on prescription. What makes them different from other acne products is that they don’t contain antibiotics. Studies show that Differin gel is a good choice for the topical treatment of acne vulgaris and has fewer side effects than other acne treatments.”

Differin Gel Adapalene FAQs

Differin adapalene cream and Differin adapalene gel contain Adapalene 0.1%. Both work in the same way to treat acne. The only difference is in the formulation. People with dry skin may prefer Differin cream over the gel as the cream has moisturising properties. On the other hand, Differin gel may be more suited to oily skin. 

Differin gel is absorbed more easily into the skin than Differin cream, but the cream can help moisturise the skin. 

Differin should NOT be used during pregnancy or if you are thinking of getting pregnant. If you fall pregnant whilst using Differin, please discontinue use immediately and speak to your doctor. You CAN use Differin while breastfeeding. To avoid exposure to the baby, you should NOT apply the product to your chest. 

You can buy Differin gel online from Click2Pharmacy. Differin is a prescription-based product, so you will need to fill out a consultation form for our pharmacy’s online acne clinic.

Differin gel is recommended for mild to moderate acne. As Differin contains the retinoid Adapalene, it can be used to treat comedonal acne

Differin gel or cream is a clinically proven treatment to clear acne and prevent breakouts. Although some people may experience fewer side effects with Differin than other topical retinoid treatments, it may not suit all skin types. The pharmacists at Click2Pharmcy can guide you on which acne treatment product may be best for you.

Rosacea was once known as “acne rosacea” but is now considered a different condition. Although Differin can be prescribed by dermatologists to treat rosacea, it cannot be prescribed online for this purpose.

Differin contains the retinoid Adapalene, and Tretinoin is also a retinoid. Both can be used successfully to treat acne, but the main differences are that Tretinoin is more potent and may cause greater irritation. In addition, products that contain Tretinoin, such as Aknemycin Plus, also contain an antibiotic, which Differin does not have.

If used every day, a 45g tube of Differin gel should last up to 90 days. 


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Customer Reviews

Based on 68 reviews
Ibrahim Ahsan
Ibrahim Ahsan
Very helpful staff, never had any issues with this pharmacy, 100% recommend
Julie Beardsley
Julie Beardsley
Very professional service. Just like having your very own pharmacist. Brilliant
Mohammed Khan
Mohammed Khan
Just had private bloods taken short wait time very thorough good price nice lady would recommend.
Sarah Smithies
Sarah Smithies
It is great to have somewhere local that does blood testing. The staff are lovely, helpful and experienced. They fit me in last minute. There is never a wait and the results back within a day or two.
After refusal of doctors appointment same old same old ring back etc. I was invited at 5.25 to see doctor I drove over immediately. Everything fully explained and checked over I was leaving by 6pm with penicillin for strep throat. Had I followed my doctors receptionist I would probably have suffered longer and increased the chances of a worse infection.I Great efficient service.
Lisa Lowther
Lisa Lowther
Fantastic service went for blood done very fast very friendly fantastic customer service

There are several products available from Click2Pharmacy to treat acne. Aknemycin Plus also contains a retinoid with the added benefit of an antibiotic to kill bacteria causing acne.