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Epiduo Gel (Adapalene and Benzoyl Peroxide) 45g


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Key Features

  • Dual-action mechanism of adapalene and benzoyl peroxide
  • Epiduo gel kills acne-causing bacteria
  • Visible results in 4 weeks
  • Buy online from Click2Pharmacy and get it delivered straight to your door.

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Epiduo Gel for Acne

A view from our expert
Picture of Sakib Mohammed

Sakib Mohammed

Advance Pharmacist Prescriber

“Epiduo gel is a medicine clinically proven to treat mild to moderate acne if you have mostly whiteheads and blackheads with a few papules and pustules. What makes Epiduo gel/cream work so well is that it has two key ingredients that work together to eradicate acne. You can use Epiduo when other single treatments have failed. Another advantage of Epiduo topical gel is that it doesn’t contain antibiotics, which is great for people who cannot tolerate them.

You do need a prescription for this medicine, but the good news is you can buy Epiduo gel from the online clinic at Click2Pharmacy. We have a team of prescribing pharmacists that can check if the medication is suitable for you. All you have to do is to fill out a consultation form. If you have any questions or concerns, we are here to help.”

Buy Epiduo Gel Online

Epiduo gel is a topical prescription-only medication designed to treat mild to moderate acne. It contains two active ingredients: adapalene and benzoyl peroxide. It is available in two different strengths: 0.1%/0.25% and 0.3/0.25%. These ingredients work together to clear your skin and prevent future breakouts.

If you’ve tried various over-the-counter acne treatments without success, Epiduo could be the solution you’re looking for. It’s a stronger option that targets multiple causes of acne, offering a comprehensive approach to clearer skin.

Medication NameEpiduo Gel
Active Ingredientadapalene and benzoyl peroxide
Medication formGel
Used to treatMild to Moderate
Available dosagesEpiduo 0.1%/0.25% gel
Epiduo 0.3%/0.25% gel
Other names by which this medication is knownEpiduo Acne Gel
Epiduo Gel
Common side effects
Itching, peeling, or burning skin
Redness of the skin
Who is this medication suitable forAdults
Children over 9 years
Do you need a prescription for it?Yes
How should it be used?Apply a thin film of gel to whole of affected area daily.
Patient Information LeafletEpiduo Patient Information Leaflet

What is Epiduo Gel used for?

Epiduo is primarily used to treat mild to moderate acne, including pimples, blackheads, and whiteheads. It’s a go-to treatment for those who need something stronger than standard over-the-counter options. 

The gel is effective against acne vulgaris, which is the medical term for common acne. This includes various types of acne, like pimples, blackheads, and whiteheads. 

Who is Epiduo acne treatment suitable for?

Epiduo is suitable for adults and children over 9 years old. It’s designed to work on all skin types but is particularly effective for those with oily skin. 

If you’re allergic to adapalene or benzoyl peroxide, you should avoid using Epiduo. Also, if you have other skin conditions like eczema, consult a GP or pharmacist before starting treatment. 

How does Epiduo Gel for acne work?

Epiduo contains adapalene and benzoyl peroxide. Adapalene helps your skin renew itself and unclogs pores. Benzoyl peroxide kills acne-causing bacteria and has a mild drying effect of washing away excess oils and dirt

Results can vary, but you may start to see improvements in as little as two weeks. However, it’s common to experience the full benefits after up to three months of regular use. 

How to Use Epiduo Gel

Follow this step-by-step guide on how to apply Epiduo gel:

  • Wash your hands before and after use
  • Wash your face with a mild cleanser.
  • Pat your face dry gently.
  • Apply a pea-sized amount of Epiduo on your chin, forehead, and each cheek.
  • Rub the gel in gently and let it dry.

It’s best to apply Epiduo at night as it can make your skin more sensitive to the sun. Make sure your skin is clean and dry before application. A small amount is effective, so don’t overuse it. 

What are the side effects of Epiduo Gel?

The side effects below affect between 1% and 10% of people:

  • Dry skin
  • Skin peeling
  • Contact dermatitis
  • Irritation and burning of the skin
  • Worsening of acne

You can minimise these side effects by using a non-comedogenic moisturiser and reducing the frequency of applying Epiduo gel until the skin becomes used to the medicine. Within the first 4 weeks of use, you may experience skin purging, where the skin looks worse before it starts to look better. Skin purging is part of the process of the renewal of skin cells.

If you experience any severe side effects listed below, you should stop using Epiduo prescription gel immediately and seek medical help.

  • Severe rash
  • Dizziness
  • Trouble breathing

For a full list of side effects, please read the patient information leaflet.

Epiduo Gel Ingredients

Active ingredients: adapalene and benzoyl peroxide
Inactive ingredients: docusate sodium, disodium edetate, glycerin, poloxamer, propylene glycerol (E1520), simulgel 600 PHA (copolymer of acrylamide and sodium acryloyldimethyltaurate, isohexadecane, polysorbate 80, sorbitan oleate) & purified water.

Important Information

  • Do NOT use Epiduo gel on broken skin or if you have eczema.
  • Epiduo gel may interfere with other acne medicines, so please speak to your doctor before starting the medication.
  • Please note that Epiduo gel contains benzoyl peroxide and has bleaching properties, so it should be kept away from fabrics.
  • For external use only.
  • Keep out of the SIGHT and REACH of children.

Buy Epiduo Gel Online from Click2Pharmacy

If you’ve been struggling with acne and think Epiduo could be your way to clearer skin, don’t wait any longer. You can buy Epiduo Gel online from Click2Pharmacy. We offer Epiduo as part of our prescription-based service. Start by completing an online assessment right on our website. You’ll then have a consultation with a qualified pharmacist who will determine if Epiduo is the right treatment for you. Once this is approved, it will be delivered discretely to your door.

Epiduo Gel FAQs

Epiduo is made of two active ingredients: adapalene 0.1% and benzoyl peroxide 2.5%

You may start seeing results in as little as two weeks, but full effects usually take up to three months

Yes, but wait until Epiduo has been absorbed into your skin before applying other products.

Both Epiduo gel and Duac gel contain benzoyl peroxide, but Duac contains the antibiotic clindamycin. Both products effectively treat acne, but for people who cannot tolerate antibiotics, Epiduo gel may be a better option.

For long-term safety, it’s best to consult a GP or pharmacist. They can provide guidance based on your skin’s response to the treatment.

Epiduo medication is NOT safe for use in pregnancy. As the effects of Epiduo on breastmilk are unknown, it is NOT recommended for breastfeeding. If you find you are pregnant whilst using Epiduo gel, you should stop use immediately.


We are regulated by the General Pharmaceutical Council

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Customer Reviews

Based on 68 reviews
Ibrahim Ahsan
Ibrahim Ahsan
Very helpful staff, never had any issues with this pharmacy, 100% recommend
Julie Beardsley
Julie Beardsley
Very professional service. Just like having your very own pharmacist. Brilliant
Mohammed Khan
Mohammed Khan
Just had private bloods taken short wait time very thorough good price nice lady would recommend.
Sarah Smithies
Sarah Smithies
It is great to have somewhere local that does blood testing. The staff are lovely, helpful and experienced. They fit me in last minute. There is never a wait and the results back within a day or two.
After refusal of doctors appointment same old same old ring back etc. I was invited at 5.25 to see doctor I drove over immediately. Everything fully explained and checked over I was leaving by 6pm with penicillin for strep throat. Had I followed my doctors receptionist I would probably have suffered longer and increased the chances of a worse infection.I Great efficient service.
Lisa Lowther
Lisa Lowther
Fantastic service went for blood done very fast very friendly fantastic customer service