Variety of delivery options including next day & free delivery.
Pharmacy, clinic and prescribers based in Greater Manchester.
Start your treatment with a quick and free online consultation.
Variety of delivery options including next day & free delivery.
Pharmacy, clinic and prescribers based in Greater Manchester.
Start your treatment with a quick and free online consultation.
Fill in a quick online consultation for our licensed pharmacists to review.
Our pharmacists will review your treatment to ensure it’s suitable.
Your treatment will be delivered to your door quickly & discreetly.
| Medication Name | Lenzetto 1.53 mg/spray Transdermal Spray |
| Medication Form | Transdermal spray solution |
| Used For | Relief of oestrogen deficiency symptoms after menopause, including hot flushes, night sweats, sleep disturbance and vaginal dryness |
| Who Can Use | Postmenopausal women with at least 6 months since their last natural period; women who have had their ovaries surgically removed |
| Active Ingredient(s) | Estradiol 1.53mg per spray (as estradiol hemihydrate) |
| Pack Size | Single bottle (56 sprays); Pack of 3 bottles (168 sprays) |
| Usual Dose | 1 to 3 sprays once daily, applied to the inner forearm or inner thigh |
| Common Side Effects | Headache, abdominal pain, nausea, skin rash, irregular vaginal bleeding, breast tenderness, weight changes |
| Prescription Required | Yes |
| Patient Information Leaflet | Lenzetto Patient Information Leaflet |
Lenzetto is a hormone replacement therapy (HRT) used to relieve symptoms caused by falling oestrogen levels after menopause. It is prescribed for postmenopausal women who are at least 6 months past their last natural period, and for women who have had surgery to remove their ovaries.
Lenzetto will only be prescribed if your symptoms are significantly affecting your daily life.
Symptoms of oestrogen deficiency that Lenzetto can help with include:
Lenzetto is not a contraceptive. If you are under 50 or fewer than 12 months have passed since your last period, you may still need additional contraception. Speak to your doctor for advice.
Lenzetto contains estradiol, a form of oestrogen that is identical to the hormone naturally produced by your body. When you spray it onto your skin, estradiol is absorbed from the skin into your bloodstream, where it replaces some of the oestrogen your body has stopped producing.
This rise in oestrogen levels helps to ease menopause symptoms that happen when levels drop, like hot flushes, night sweats, and sleep disturbance.
If you still have your womb, your doctor will prescribe a separate progestogen alongside Lenzetto. Taking oestrogen alone can cause the lining of the womb to thicken over time, which increases the risk of endometrial cancer. Progesterone counteracts this effect and makes the treatment safe for women who have not had a hysterectomy.
Lenzetto is suitable for postmenopausal women with at least 6 months since their last natural period, and for women who have had surgery to remove their ovaries.
Do not use Lenzetto if you:
Speak to your doctor before using Lenzetto if you have or have ever had:
Before using a new container, the pump should be primed by spraying three times with the cover on. You only need to do this once per container. If you miss one or more doses, re-prime with one spray (cover on) before continuing.
Do not rub or massage the spray into the skin.
Let the spray dry for at least 2 minutes before getting dressed and 60 minutes before bathing. If Lenzetto gets onto your hands or anywhere else, wash with soap and water straight away. Keep others, especially children, away from the treated area until it has dried.
Your doctor will start you on one spray per day, increasing to a maximum of three sprays if needed. Apply your daily dose at the same time each day and review your treatment with your doctor every 3 to 6 months.
If you forget to use the spray, apply it as soon as you remember. If your next dose is due soon, skip the missed one. Do not double-dose.
Like all medicines, Lenzetto can cause side effects, though not everyone experiences them.
Common side effects may affect up to 1 in 10 people:
Uncommon side effects may affect up to 1 in 100 people:
Rare side effects may affect up to 1 in 1,000 people:
For a full list of side effects, read the Lenzetto patient information leaflet.
If you notice any side effects, tell your doctor or pharmacist. You can also report side effects directly via the Yellow Card Scheme.
Active ingredient: Estradiol 1.53 mg per spray (as estradiol hemihydrate 1.58 mg)
Other ingredients: Octisalate, ethanol 96%
Each spray of Lenzetto contains 1.53 mg of estradiol, while each pump of Oestrogel delivers 0.75 mg. Both are forms of oestrogen replacement, but Lenzetto contains a higher dose of oestrogen per application than other oestrogen-only HRT products. That said, the right dose for you will depend on your symptoms and your doctor’s assessment; both products are titrated to the lowest effective dose.
The inner forearm is the recommended site. If this is not practical, the inner thigh can be used instead. Do not apply Lenzetto to the breasts, broken skin, or any area near the breasts.
Both Lenzetto and HRT patches deliver estradiol transdermally, so the hormone itself works in the same way. The difference is the format. Lenzetto is a metered-dose spray applied daily to the skin, while patches are adhesive and changed every few days. The best option depends on personal preference and your doctor’s recommendation. Some women prefer a spray as there is no patch to adhere to the skin, while others find patches more convenient.
Weight changes (both increase and decrease) are listed as common side effects of Lenzetto, meaning they may affect up to 1 in 10 people. If you notice significant changes in your weight after starting treatment, speak to your doctor.
You can order Lenzetto through our online menopause clinic at Click2Pharmacy. Complete a short consultation and our licensed pharmacists will review your request. If suitable, your treatment will be dispensed and delivered to your door quickly and discreetly.
You should wait at least 60 minutes after applying Lenzetto before bathing, showering or swimming. Washing the area too soon may affect how much estradiol is absorbed through the skin. Allow at least 2 minutes for the spray to dry before getting dressed.
The most important thing is to apply it at the same time every day. Choose a time that works for your routine; some women prefer mornings as part of a skincare routine, while others find it easier at night.
Apply the spray as soon as you remember. If your next dose is due soon, skip the missed dose and continue as normal. Do not apply a double dose. If you have missed one or more doses, re-prime the pump with one spray (with the cover on) before your next dose.
Page content authored by Amjad Khan, last reviewed by Mr Muhammad on 13th April 2026.
Get 10% Off Your First Order
Sign up to receive special offers via email and get 10% off your first order*
By opting in to marketing, you agree to our terms & conditions and privacy policy.
