Variety of delivery options including next day & free delivery.
Pharmacy, clinic and prescribers based in Greater Manchester.
Start your treatment with a quick and free online consultation.
Variety of delivery options including next day & free delivery.
Pharmacy, clinic and prescribers based in Greater Manchester.
Start your treatment with a quick and free online consultation.
Fill in a quick online consultation for our licensed pharmacists to review.
Our pharmacists will review your treatment to ensure it’s suitable.
Your treatment will be delivered to your door quickly & discreetly.
| Medication Name | Oestrogel Pump-Pack 750 Micrograms/Actuation Gel |
| Medication Form | Transdermal gel |
| Used for | Relief of menopausal symptoms; prevention of osteoporosis after menopause |
| Who can use | Postmenopausal women |
| Active Ingredient | Estradiol 750 micrograms per actuation (as hemihydrate) |
| Usual Dose | Once daily |
| Common Side Effects | Headache, nausea, abdominal pain, breast pain, abnormal bleeding |
| Prescription Required | Yes |
| Patient Information Leaflet | Oestrogel Pump-Pack Patient Information Leaflet |
Oestrogel is a topical HRT gel used in postmenopausal women. It contains estradiol, a form of oestrogen, and is prescribed to help manage the symptoms of menopause.
Oestrogel is used for:
During the menopause, your body produces less oestrogen. This drop in hormone levels is what causes symptoms like hot flushes, night sweats, and mood changes.
Oestrogel works by replacing the oestrogen your body is no longer making. The gel is applied to your arms or thighs, where estradiol is absorbed directly into the bloodstream. This raises your oestrogen levels back to a range similar to before the menopause, helping to ease symptoms.
Because Oestrogel is a transdermal gel, the hormone bypasses the digestive system and goes straight into the bloodstream through the skin.
Oestrogel is suitable for postmenopausal women whose symptoms are seriously affecting their daily life, or who are at increased risk of osteoporosis after menopause.
Do not use Oestrogel if you:
Speak to your doctor before using Oestrogel if you have ever had any of the following:
Your doctor will assess whether Oestrogel is suitable based on your medical history and any risk factors you may have.
Apply the gel once a day at the same time each day, either in the morning or in the evening. If you are unsure how many pumps to use, follow your doctor’s instructions – the dose of gel that has been prescribed will be the lowest amount needed to manage your symptoms.
If you are switching from another type of HRT, finish your current pack before starting Oestrogel.
Before using a new pump pack for the first time, prime it by pressing the plunger down a few times until the gel comes out, then discard that first dose of gel before you use it:
Don’t apply your daily dose on or near the breasts or genital area. Avoid applying other skin products to the area for at least one hour after use.
Like all medicines, Oestrogel can cause side effects, though not everyone experiences them.
These may affect up to 1 in 10 people:
These may affect up to 1 in 100 people:
These may affect up to 1 in 1,000 people:
For a full list of side effects, read the Oestrogel Pump-Pack Patient Information Leaflet.
If you experience any severe side effects or signs of an allergic reaction, stop using Oestrogel and seek immediate medical attention by calling 999 or going to A&E.
If you notice any side effects, tell your doctor or pharmacist even if they are not listed here.
You can also report side effects through the Yellow Card Scheme.
Active ingredient: Estradiol 750 micrograms per actuation (as hemihydrate), 0.06% w/w
Other ingredients: Carbomer, trolamine, ethanol, purified water
Oestrogel replaces the oestrogen your body stops producing after the menopause. By absorbing estradiol through the skin, it raises your oestrogen levels back to a range similar to before the menopause. This helps relieve symptoms like hot flushes, night sweats, and mood changes, and can also help protect against bone loss (osteoporosis) in women at increased risk.
Apply Oestrogel to either the outer arms and shoulders, or the mid-inner thighs. Spread each pump over a large area of skin for the best absorption. Never apply it on or near the breasts or genital area.
There is no clinical difference between applying Oestrogel in the morning or evening. The most important thing is to apply it at the same time each day. Choose whichever time fits most easily into your routine and stick to it.
Avoid applying other skin products, cosmetics, or sunscreen to the same area for at least one hour after applying the gel. Don’t wash the application site for at least one hour, avoid close skin contact with your partner for one hour after application, and keep the area covered until the gel has dried to prevent accidental transfer – particularly to children.
At the standard dose of 2 pumps per day, each pump pack lasts 4 weeks. If you have been prescribed 4 pumps per day, it will last two weeks.
Most women notice an improvement in symptoms within a few weeks of starting treatment. However, it can take up to three months to feel the full benefit. If your symptoms haven’t improved after this time, speak to your doctor.
You can buy Oestrogel pump-pack online through our menopause and HRT clinic at Click2Pharmacy. Just complete a short online consultation, which will be reviewed by one of our licensed pharmacists, and your treatment will be delivered quickly and discreetly to your door.
Yes, but not at the same time or on the same area. Wait at least one hour after applying Oestrogel before using moisturisers, sunscreens, or other skin products on the application site. Applying other products too soon can affect how well the gel is absorbed through the skin.
Weight change is listed as a common side effect of Oestrogel, affecting up to 1 in 10 people. However, some weight changes around the menopause are related to hormonal shifts rather than HRT itself. If you are concerned about changes in your weight while using Oestrogel, speak to your doctor.
If you miss a dose and your next dose is more than 12 hours away, apply it as soon as you remember. Otherwise, skip it and continue as normal. Never use 2 doses at once to make up for a missed one. Missing a dose may cause breakthrough bleeding or spotting.
Page content authored by Amjad Khan, last reviewed by Mr Muhammad on 25th March 2026.
Get 10% Off Your First Order
Sign up to receive special offers via email and get 10% off your first order*
By opting in to marketing, you agree to our terms & conditions and privacy policy.
