Variety of delivery options including next day & free delivery.
Pharmacy, clinic and prescribers based in Greater Manchester.
Start your treatment with a quick and free online consultation.
Variety of delivery options including next day & free delivery.
Pharmacy, clinic and prescribers based in Greater Manchester.
Start your treatment with a quick and free online consultation.
Fill in a quick online consultation for our licensed pharmacists to review.
Our pharmacists will review your treatment to ensure it’s suitable.
Your treatment will be delivered to your door quickly & discreetly.
| Medication Name | Nytol One-A-Night Tablets |
| Medication Form | Tablets |
| Used for | Temporary sleeping difficulties |
| Active Ingredients | Diphenhydramine Hydrochloride |
| Strength | 50mg |
| Patient Information Leaflet | Nytol One-A-Night Patient Information Leaflet |
If you’re struggling with temporary sleeplessness, Nytol One-A-Night 50mg is here to help.
This clinically proven sleep aid works to ease you into a deeper, more restful sleep, perfect for nights when stress, jet lag, or other short-term issues keep you awake. It’s designed to help you get back into a regular sleep rhythm so you can wake up refreshed and ready to tackle the day.
The active ingredient in Nytol One-A-Night 50mg tablets is Diphenhydramine Hydrochloride, an antihistamine that makes you sleepy. It blocks chemicals in your body that keep you awake, helping you drift off more easily.
Nytol sleeping tablets are for adults aged 18 and over.
Do not take it if:
As part of your nightly routine, take one tablet with water around 20 minutes before going to bed. Nytol One-A-Night usually begins working within 20-30 minutes. Stick to the recommended dose and avoid taking an extra tablet if you wake up during the night.
Like all medications, Nytol One-A-Night may cause side effects, although not everyone experiences them:
If you experience severe side effects, such as blurred vision or signs of an allergic reaction, stop using Nytol One-A-Night and call NHS 111 or go to A&E immediately. For a full list of side effects of taking Nytol One-A-Night, read the patient information leaflet.
If you experience any side effects, let your doctor or pharmacist know, even if they aren’t mentioned in the leaflet. You can also report side effects directly using the Yellow Card Scheme. Sharing this information helps improve the safety knowledge of this medication.
Active Ingredient: Diphenhydramine Hydrochloride
Inactive Ingredients: Lactose, maise starch, stearic acid, and others
Nytol One-A-Night is an over-the-counter sleeping aid in the UK.
When you order Nytol online from Click2Pharmacy, you’ll need to complete a brief online consultation to make sure the tablets are suitable for you. Our pharmacists will review your information and send out Nytol One-A-Day once it has been approved. You can choose from various delivery options, including Nytol next-day delivery, to get your sleep aid quickly.
You can take Nytol One-A-Night if you’ve used sleeping aids in the past, as long as you have not had a reaction to its active ingredient, Diphenhydramine Hydrochloride. However, it’s important to avoid taking Nytol tablets and other sleeping aids at the same time.
Do not combine Nytol Original and Nytol One-A-Night, as this will exceed the recommended dosage of the active ingredients. If you’re unsure, consult your doctor or pharmacist before taking it.
Nytol One-A-Night is intended for short-term use to help relieve temporary sleeping difficulties. Taking it every night for an extended period is not recommended, as this may reduce its effectiveness over time. If you’re experiencing ongoing sleep difficulties, consult your doctor to explore other solutions.
Do not use other antihistamines while taking these tablets, as combining them can increase the risk of side effects. This includes antihistamines found in skin creams, as well as those used in cough and cold medicines.
Nytol One-A-Night works by calming the arousal-promoting areas of the brain, helping you move through each stage of sleep without interruption. The effects generally last around 8 hours, giving you the restful sleep you need to feel refreshed. You should avoid driving or operating machinery during this time, as drowsiness may continue after waking.
If you feel like the effects of Nytol One-A-Night sleep aids last too long, try switching to Nytol Original or Nytol Herbal tablets. Nytol Original contains a lower dose of the same active ingredient, which may not stay in your system as long. Nytol Herbal is a natural sleep aid tablet that doesn’t contain the same active ingredient, making it a gentler option.
Nytol One-A-Night contains 50mg of Diphenhydramine Hydrochloride per tablet, and it is recommended that you take only the advised dose of Nytol.
If you accidentally take two tablets instead of taking a single tablet, you may feel very drowsy or experience other side effects. Avoid activities like driving or operating machinery and rest until the effects wear off.
If you notice severe symptoms or feel unwell, contact your doctor or pharmacist immediately for advice on how to manage taking this medicine.
Nytol One-A-Night can interact with certain antidepressants, particularly monoamine oxidase inhibitors (MAOIs) and tricyclic antidepressants.
These interactions may increase side effects like drowsiness, dry mouth, or confusion. If you are taking antidepressants, it’s important to talk to your doctor or pharmacist before using Nytol One-A-Night to make sure it’s safe for you.
“Nytol One-A-Night is a great choice if you’re struggling to drift off to sleep. Its simple one-tablet formula helps you fall asleep faster and wake up feeling refreshed.”
Dr Hussain Ahmad
Page content authored by Mr Mohammed, last reviewed by Amjad Khan on 8th April 2026.
