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Cyclizine Hydrochloride Tablets (50mg)

  • Antihistamine tablets for nausea and vomiting
  • Helps prevent travel and motion sickness
  • Suitable for adults and children aged 6+
  • 20 tablets (short term use only. Not suitable for repeat orders)
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Pharmacy, clinic and prescribers based in Greater Manchester.

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Cyclizine Hydrochloride Tablets

Medication Name Cyclizine Hydrochloride 50mg Tablets
Medication Form Tablet
Used For Nausea and vomiting, including travel sickness, post-operative nausea and inner ear conditions such as MĂ©nière’s disease
Who Can Use Adults and children aged 6 and over
Active Ingredient(s) Cyclizine hydrochloride 50mg
Usual Dose Adults and children aged 12 and over: 1 tablet up to 3 times daily.

Children aged 6 to 12: half a tablet up to 3 times daily

Common Side Effects Drowsiness, dry mouth, headache, blurred vision
Prescription Required Yes
Patient Information Leaflet Cyclizine Hydrochloride Tablets PIL

What are Cyclizine Hydrochloride Tablets used for?

Cyclizine sickness tablets are used to prevent and treat nausea and vomiting. They can be used for a number of different causes, including:

  • Travel and motion sickness: if you feel sick or vomit when travelling by car, boat, plane or train
  • Post-operative nausea: general anaesthetics can sometimes cause sickness after surgery
  • Radiotherapy-induced nausea: cyclizine can help manage nausea caused by cancer treatment
  • Medicine-induced nausea: some medicines can cause nausea as a side effect
  • Inner ear conditions: cyclizine can treat sickness linked to conditions such as MĂ©nière’s disease, where a problem in the inner ear causes vertigo, dizziness and nausea

How do Cyclizine Hydrochloride Tablets work?

Cyclizine tablets belong to a group of medicines called antihistamines. It’s used to treat nausea and vomiting by blocking signals in the brain that trigger the feeling of sickness.

When something upsets the body’s balance, such as motion, a medicine, an anaesthetic, or an inner ear problem, the brain receives signals that trigger nausea and vomiting. Cyclizine helps interrupt these signals before they can take effect, helping to settle the feeling of sickness.

Who can use Cyclizine Hydrochloride Tablets?

Cyclizine 50mg tablets are suitable for adults and children aged 6 and over.

Don’t take cyclizine if you:

  • Are allergic to cyclizine hydrochloride or any of the other ingredients
  • Have been drinking alcohol

Speak to your pharmacist or doctor before taking these tablets if you have:

  • Glaucoma (increased pressure in the eye)
  • Difficulty passing urine
  • A bowel blockage
  • Liver problems
  • A tumour of the adrenal glands (phaeochromocytoma)
  • High blood pressure
  • Epilepsy
  • An enlarged prostate gland
  • Heart failure
  • Porphyria (an inherited sensitivity to sunlight)
  • Been told you are intolerant to some sugars, as the tablets contain lactose

Other Medicines and Cyclizine

Tell your doctor or pharmacist if you’re taking any other medicines, particularly:

  • Medicines for depression, anxiety or difficulty sleeping
  • Strong painkillers such as pethidine
  • Anticholinergic medicines (your doctor or pharmacist can advise if any of your medicines fall into this category)

You should also speak to your doctor or pharmacist before taking cyclizine if you are pregnant or breastfeeding.

How to Take Cyclizine Hydrochloride Tablets

Always take the exact cyclizine dosage as your doctor or pharmacist has told you. Swallow the tablets with a little water.

  • Adults and children aged 12 and over: 1 tablet up to 3 times daily
  • Children aged 6 to 12: half a tablet up to 3 times daily. The tablet has a score line on one side so it can be divided into two equal halves

Don’t give cyclizine to children under 6 years old.

Side Effects of Cyclizine Hydrochloride Tablets

Like all medicines, cyclizine carries a risk of side effects, though not everyone gets them.

The following side effects have been reported with cyclizine. The frequency of these isn’t known:

  • Drowsiness
  • Headache
  • Dizziness
  • Dry mouth, nose or throat
  • Blurred vision
  • Fast or irregular heartbeat
  • Difficulty passing urine
  • Constipation, heartburn, nausea, vomiting, diarrhoea or stomach pain
  • Skin rashes or itching
  • Restlessness, nervousness or difficulty sleeping
  • Confusion or hallucinations
  • Muscle twitches, tremors or unusual body movements
  • Seizures
  • Yellowing of the skin or whites of the eyes (jaundice)
  • Increased sensitivity to sunlight

Stop taking cyclizine and tell your doctor straight away if you notice any signs of an allergic reaction, including:

  • Itching or a skin rash
  • Swelling of the face, lips or throat
  • Difficulty breathing or wheezing

If you experience any severe side effects or signs of an allergic reaction, stop taking cyclizine and seek immediate medical attention by calling 999 or going to A&E.

For a full list of side effects, read the patient information leaflet.

Reporting Side Effects

If you notice any side effects, tell your doctor or pharmacist even if they’re not listed here. You can also report side effects through the Yellow Card Scheme. This helps improve the safety of this medicine.

Cyclizine Hydrochloride Tablets Ingredients

Active ingredient: Cyclizine hydrochloride 50mg

Other ingredients: Lactose, potato starch, acacia, magnesium stearate

Warnings and Precautions

  • Keep out of the sight and reach of children
  • Don’t use after the expiry date shown on the carton or label
  • Store below 25°C
  • Don’t throw away medicines via wastewater or household waste. Ask your local pharmacy or pharmacist how to dispose of medicines you no longer need
  • Don’t drink alcohol while taking cyclizine. Alcohol can increase the side effects of the medicine
  • Cyclizine may cause drowsiness or make you feel dizzy. Don’t operate machinery or drive while taking cyclizine hydrochloride until you know how it affects you

Other Medicines and Cyclizine

Tell your doctor or pharmacist if you’re taking any other medicines, particularly:

  • Medicines for depression, anxiety or difficulty sleeping
  • Strong painkillers such as pethidine
  • Anticholinergic medicines (your doctor or pharmacist can advise if any of your medicines fall into this category)

Cyclizine Hydrochloride Tablets (50mg) Reviews

Cyclizine Hydrochloride Tablets FAQs


Avoid alcohol while taking cyclizine, as this can increase the side effects of the medicine. You should also avoid driving or operating machinery until you know how cyclizine affects you, as it can cause drowsiness and dizziness.

If you’re taking any other medicines, particularly those for depression, anxiety or sleep problems, tell your doctor or pharmacist before starting cyclizine, as some medicines can interact with it.

Don’t take cyclizine if you’re allergic to any of its ingredients or if you’ve been drinking alcohol. It’s also not suitable for children under 6 years old.

If you have certain health conditions, cyclizine may not be appropriate for you. Speak to your doctor before taking it if you have glaucoma, heart failure, liver problems, epilepsy or an enlarged prostate, among other conditions.

If you know something is likely to make you feel sick, such as travelling, take cyclizine beforehand to help stop nausea before it starts. For travel sickness, it’s best taken 1-2 hours before your journey.

If you’re taking cyclizine for post-operative nausea or another condition, follow the timing advised by your doctor or pharmacist.

Don’t take cyclizine after the expiry date printed on the carton or label after “EXP.” If you have any tablets you no longer need, ask your pharmacist how to dispose of them safely.

Cyclizine hydrochloride 50mg tablets are a prescription-only medicine and can’t be bought over the counter. You can request a prescription through our online clinic by completing a short survey, which our pharmacists will review.

Adults and children aged 12 and over can take cyclizine up to 3 times daily. Children aged 6 to 12 can take half a tablet up to 3 times daily. Don’t exceed the recommended dose.

You should speak to your doctor or pharmacist before taking cyclizine alongside any other antihistamines. Combining antihistamines can increase the risk of side effects such as drowsiness.

Take your next dose at the usual time. Don’t take a double dose to make up for a missed one.

Contact your doctor or the emergency department at your nearest hospital immediately if you take more than you should. Take the leaflet or packaging with you to show what you’ve taken.

Our Experienced UK-based Pharmacy Team

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Page content authored by Amjad Khan, last reviewed by Mr Muhammad on 3rd June 2026.