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| Medication Name | Xonvea 10mg/10mg Gastro-Resistant Tablets |
| Medication Form | Gastro-resistant tablet |
| Used For | Nausea and vomiting during pregnancy |
| Who Can Use | Pregnant women aged 18 and over |
| Active Ingredient(s) | Doxylamine succinate 10mg, pyridoxine hydrochloride 10mg |
| Usual Dose | 2 tablets at bedtime, up to a maximum of 4 tablets per day |
| Common Side Effects | Sleepiness, dizziness, tiredness, dry mouth |
| Prescription Required | Yes |
| Patient Information Leaflet | Xonvea Tablets Patient Information Leaflet |
Xonvea is used to treat nausea and vomiting during pregnancy, commonly known as morning sickness (or pregnancy sickness). It’s prescribed for pregnant women when changes to diet or other non-medicine approaches haven’t been enough to control symptoms.
Morning sickness affects most pregnant women, particularly in the first trimester, and symptoms can include:
If you’re experiencing severe nausea and vomiting of pregnancy that leads to dehydration or significant weight loss, this may be a condition called hyperemesis gravidarum, which requires specialist medical care and isn’t treated with Xonvea alone.
Xonvea contains two active ingredients that work together to reduce nausea and vomiting during pregnancy.
Doxylamine succinate is an antihistamine. In addition to blocking histamine, it acts on the part of the brain that controls nausea and vomiting, helping reduce the urge to be sick.
Pyridoxine hydrochloride is vitamin B6. Low levels of vitamin B6 have been linked to nausea during pregnancy, and supplementing it can help ease symptoms.
Together, doxylamine and pyridoxine complement each other, providing more effective relief than they would individually.
Xonvea is suitable for pregnant women aged 18 and over who are experiencing nausea and vomiting during pregnancy.
Don’t take Xonvea if you:
Speak to your doctor or pharmacist before taking Xonvea if you have:
Xonvea isn’t suitable for anyone under 18 years old.
Always take Xonvea exactly as your doctor or pharmacist has told you. Swallow each tablet whole with a glass of water on an empty stomach. Don’t crush, chew or split the tablets.
Your doctor will start you on a low dose and increase it if needed, based on how well your symptoms are controlled.
Days 1 and 2: Take 2 tablets at bedtime.
Day 3: If your symptoms are still not controlled, take 1 tablet in the morning and 2 tablets at bedtime.
Day 4 onwards: If symptoms are still not controlled, take 1 tablet in the morning, 1 in the mid-afternoon and 2 at bedtime. This is the maximum dose.
Don’t take more than 4 tablets in a single day.
Like all medicines, Xonvea can cause side effects, though not everyone experiences them.
May affect more than 1 in 10 people:
May affect up to 1 in 10 people:
The following have been reported but how often they occur isn’t known:
For a full list of side effects, read the Xonvea patient information leaflet.
If you experience a severe side effect or signs of an allergic reaction, stop taking Xonvea and seek immediate medical attention by calling 999 or going to A&E.
You can report any side effects directly through the Yellow Card Scheme. This helps improve the safety of medicines for everyone.
Active ingredients: Doxylamine succinate 10mg, pyridoxine hydrochloride 10mg
Other ingredients: Carnauba wax, croscarmellose sodium, hypromellose (E 464), indigo carmine aluminium lake (E 132), macrogol (E 1521), magnesium stearate, magnesium trisilicate, methacrylic acid-ethyl acrylate copolymer (1:1), microcrystalline cellulose, Allura red AC aluminium lake (E 129), polysorbate 80 (E 433), propylene glycol (E 1520), colloidal anhydrous silica, shellac, simethicone emulsion, benzoic acid (E 210), sodium hydrogen carbonate (E 500), sodium lauril sulfate (E 487), talc (E 553b), titanium dioxide (E 171), triethyl citrate and simethicone.
This medicine contains the colouring agent Allura red AC aluminium lake (E 129), which may cause allergic reactions in some people.
Xonvea is specifically licensed for use during pregnancy and is only prescribed to pregnant women. As with any medicine taken during pregnancy, it should only be used as directed by your doctor or pharmacist, who will assess whether it’s right for you.
Xonvea should be taken on an empty stomach. Swallow each tablet whole with a glass of water and avoid crushing, chewing or splitting them, as this can affect how the medicine works.
Xonvea are gastro-resistant tablets, which means they don’t dissolve in the stomach. It’s important to swallow them whole, not crush, chew, or split them, as this can affect how the medicine works.
Stop taking Xonvea and contact a doctor or go to hospital straight away, even if you feel well. Take the medicine pack with you. Signs of taking too much can include restlessness, sleepiness, dizziness, dry mouth, confusion or a fast heart rate.
Don’t stop taking Xonvea without first speaking to your doctor. Stopping suddenly may cause your nausea and vomiting to return. If symptoms persist, speak to your doctor. They will advise you on how to gradually reduce your dose.
Page content authored by Amjad Khan, last reviewed by Dr Hussain Ahmad on 7th May 2026.
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