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| Medication Name | Gepretix Soft Capsules |
| Medication Form | Soft capsule |
| Used for | Menopausal symptoms, as part of combined HRT with oestrogen |
| Who can use | Postmenopausal women who have a womb |
| Active Ingredient(s) | Progesterone |
| Available Dosage | 100mg or 200mg |
| Common Side Effects | Headache, dizziness, drowsiness, nausea, stomach pain, tiredness |
| Prescription Required | Yes |
| Patient Information Leaflet | Gepretix 100mg Patient Information Leaflet |
Gepretix is used as part of hormone replacement therapy (HRT) to help reduce the symptoms of the menopause. Available as 100mg or 200mg oral capsules, it’s taken alongside an oestrogen-only HRT and is only suitable for women who still have a womb.
When oestrogen is taken on its own as HRT, it can cause the lining of the womb to thicken over time, which increases the risk of endometrial cancer. Gepretix provides the progestogen element of combined HRT, which counteracts this effect and keeps the womb lining healthy.
Common menopausal symptoms that combined HRT may help with include:
Gepretix isn’t a contraceptive. If you are under 50 or have had a period in the last 12 months, you may still need to use additional contraception. Speak to your doctor for advice.
As you approach the menopause, your body produces less oestrogen and progesterone. This drop in hormones is what causes menopausal symptoms.
HRT works by replacing these hormones. Oestrogen addresses the symptoms directly, while Gepretix provides the progesterone your body needs to protect the womb lining. By taking Gepretix alongside your oestrogen, you shed the womb lining regularly, which triggers a monthly withdrawal bleed similar to a light period.
Gepretix is suitable for postmenopausal women with an intact uterus who are already using or starting oestrogen HRT.
Don’t take Gepretix if you:
Speak to your doctor before taking Gepretix if you have or have ever had:
Always take Gepretix exactly as your doctor has told you. Your doctor will aim to prescribe the lowest effective dose for the shortest time necessary.
The recommended dose is 200 mg daily at bedtime on day 15 to day 26 of your 28-day cycle. Alternatively, your doctor may prescribe 100 mg capsules to be taken at bedtime from day 1 to day 25 of each therapeutic cycle.
Swallow the oral capsules whole with a glass of water. Don’t take them with food. Taking Gepretix at bedtime helps reduce the drowsiness and dizziness that some women experience.
Continue taking your oestrogen HRT every day as normal. After your course of Gepretix each month, you will usually have a few days of withdrawal bleeding, similar to a light period.
Like all medicines, Gepretix can cause side effects, though not everyone experiences them.
The following side effects have been reported:
Side effects observed in clinical trials also include:
Women using HRT have also been reported to experience gallbladder disease, skin discolouration, fluid retention, weight changes, hair loss, insomnia, and changes in sexual desire. For a full list of side effects, read the Gepretix Patient Information Leaflet.
If you experience any severe side effects or signs of an allergic reaction, stop taking Gepretix and seek immediate medical attention by calling 999 or going to A&E.
If you notice any side effects, tell your doctor or pharmacist even if they aren’t listed here. You can also report side effects through the Yellow Card Scheme to help improve the safety of this medicine.
Each capsule contains 100mg of progesterone.
Other ingredients: Grape seed oil, soya bean lecithin
Capsule shell: Gelatin, glycerol, titanium dioxide (E171)
Gepretix contains soya bean lecithin. Don’t use this medicine if you are allergic to peanuts or soya.
Gepretix 100mg soft capsules are halal certified.
Gepretix 100mg soft capsules are kosher certified.
No, Gepretix capsules aren’t vegan. The capsule shell contains gelatin, which comes from animals. If you need a vegan alternative, speak to your doctor or pharmacist about other progesterone options.
Gepretix and Utrogestan are both 100mg progesterone soft capsules and work in the same way. They contain the same active ingredient at the same strength and are used for the same purpose as part of combined HRT. The main difference is the brand and manufacturer. Your doctor or pharmacist can advise on which is most suitable for you.
Weight changes are listed as a possible side effect of HRT in general, but aren’t commonly reported specifically with Gepretix. If you notice significant or unexplained weight changes after starting treatment, speak to your doctor.
Tiredness and drowsiness are possible side effects of Gepretix. This is why it is recommended to take it at bedtime, which helps to minimise the impact on your daily life. If you find that drowsiness is affecting you during the day, speak to your doctor.
Headaches are a known side effect of Gepretix. If your headaches are severe, happen for the first time after starting treatment, or feel different to headaches you have had before, stop taking Gepretix and speak to your doctor.
Hair loss (alopecia) is listed as a possible side effect of HRT. It’s not commonly reported with Gepretix specifically, but if you notice changes to your hair after starting treatment, speak to your doctor.
Gepretix starts working to protect the womb lining from your first course of treatment. In terms of overall symptom relief from combined HRT, most women notice an improvement within a few weeks, though it can take up to three months to feel the full benefit.
Gepretix doesn’t stop periods altogether. As part of a sequential HRT regimen, it triggers a monthly withdrawal bleed at the end of each cycle, similar to a light period. This is expected and normal. If you experience unexpected bleeding outside of this pattern, speak to your doctor.
Gepretix is recommended to be taken at bedtime. This is because it can cause drowsiness and dizziness, which are much less likely to affect you while you sleep. Taking it in the morning may impair your ability to drive or perform daily activities safely.
Constipation isn’t listed as a known side effect of Gepretix. If you are experiencing digestive issues after starting treatment, speak to your doctor or pharmacist.
If you forget to take a capsule, take it as soon as you remember. If it is nearly time for your next dose, skip the missed one and carry on as normal. Do not take a double dose to make up for a forgotten capsule.
If you are due to have surgery, tell your surgeon that you are taking HRT. You may need to stop taking Gepretix 4 to 6 weeks before the operation to reduce the risk of blood clots. Ask your doctor when it is safe to restart your treatment.
Page content authored by Amjad Khan, last reviewed by Mr Muhammad on 26th March 2026.
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