Sayana Press Injection

About Sayana Press Injection

Sayana Press is a long-acting reversible contraceptive (LARC) containing medroxyprogesterone acetate 104mg. It is a hormonal injection used to prevent pregnancy by inhibiting ovulation, thickening cervical mucus to block sperm, and thinning the womb lining. Unlike traditional contraceptive injections administered by a professional, Sayana Press features the Uniject system, allowing for self-administration into the thigh or abdomen every 13 weeks.

Sayana Press provides highly effective, discreet protection for women who prefer not to take a daily pill. It is suitable for women of childbearing age, including adolescents (following a clinical consultation).

What Is Sayana Press Injection Used For?

Sayana Press is used for long-term contraception. It is particularly beneficial for those who find daily tablets difficult to remember or who cannot use estrogen-based contraceptives. A single injection provides 13 weeks of continuous protection against pregnancy.

Who Is Sayana Press Injection Suitable For?

Sayana Press is suitable for most women of reproductive age.

Do not use Sayana Press if you:

• Are allergic to medroxyprogesterone acetate or any listed ingredients
• Have or suspect you have breast or genital tract cancer
• Have unexplained vaginal bleeding
• Have active liver disease or a history of blood clots (thrombosis)
• Are pregnant

Speak to a healthcare professional before use if you:

• Have risk factors for osteoporosis (thinning bones)
• Have a history of depression, diabetes, or high blood pressure
• Experience migraines or severe headaches
• Have a history of heart disease or stroke

Ingredients

Other ingredients: Macrogol 3350, sodium chloride, methyl parahydroxybenzoate (E218), propyl parahydroxybenzoate (E216), polysorbate 80, monobasic sodium phosphate monohydrate, dibasic sodium phosphate dodecahydrate, methionine, povidone, sodium hydroxide/hydrochloric acid (for pH adjustment), and water for injections.

How to Use Sayana Press Injection

1. Ensure the medication is at room temperature and shake the injector vigorously for 30 seconds to mix.
2. Hold the injector upright and activate it by pushing the needle cap firmly until it clicks.
3. Remove the needle cap and gently pinch a fold of skin on the abdomen or upper thigh.
4. Insert the needle fully at a 90-degree angle and squeeze the reservoir slowly (about 5–7 seconds) to deliver the dose.
5. Withdraw the needle and discard the unit in a sharps bin. Do not rub the injection site.

Possible Side Effects of Sayana Press

Common side effects:

• Changes in menstrual cycle (irregular bleeding or stopping of periods)
• Weight gain
• Headache or abdominal pain
• Injection site reactions (pain or skin dimpling)

Uncommon:

• Decreased libido (sex drive)
• Depression or mood swings
• Nausea and acne

Long-term use is associated with a reduction in bone mineral density. Your doctor will reassess your treatment every 2 years to ensure the benefits outweigh the risks to your bone health.

Warnings and Precautions

• Does not protect against HIV (AIDS) or other sexually transmitted infections (STIs).
• May cause a delay in the return of fertility (conception may take up to a year after stopping).
• Regularly check for breast lumps while using hormonal contraception.
• If you miss a dose (more than 14 weeks since the last injection), you must exclude pregnancy before the next dose.

Storage Instructions

• Do not refrigerate or freeze.
• Keep out of sight and reach of children.
• Store in the original packaging to protect from light.